Agreement Between Magnetic Resonance Imaging Proton Density Fat Fraction Measurements and Pathologist-Assigned Steatosis Grades of Liver Biopsies From Adults With Nonalcoholic Steatohepatitis

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 153; no. 3; pp. 753 - 761
• Main Authors: Middleton, Michael S., Heba, Elhamy R., Hooker, Catherine A., Bashir, Mustafa R., Fowler, Kathryn J., Sandrasegaran, Kumar, Brunt, Elizabeth M., Kleiner, David E., Doo, Edward, Van Natta, Mark L., Lavine, Joel E., Neuschwander-Tetri, Brent A., Sanyal, Arun, Loomba, Rohit, Sirlin, Claude B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2017
• Subjects: Adiposity; Adult; Area Under Curve; Biopsy; Chenodeoxycholic Acid - analogs & derivatives; Chenodeoxycholic Acid - therapeutic use; Direct Comparison; Female; FLINT; Gastroenterology and Hepatology; Humans; Liver - pathology; Magnetic Resonance Imaging - methods; Male; Middle Aged; NAFLD; Non-alcoholic Fatty Liver Disease - diagnostic imaging; Non-alcoholic Fatty Liver Disease - pathology; Non-Invasive; ROC Curve; Single-Blind Method; NAFLD; MRI; Direct Comparison; CI; ROC; AUROC; EOT; NASH; ROI; PDFF; RCC; FLINT; Non-Invasive; CRN; positive predictive value; NAS; magnetic resonance spectroscopy; Digital Imaging and Communications in Medicine; nonalcoholic steatohepatitis; clinical research network; NAFLD activity score; Hematoxylin and eosin; DCC; body mass index; H&E; proton density fat fraction; nonalcoholic fatty liver disease; time to echo; CAP; GRE; negative predictive value; standard deviation; gradient-recalled echo; magnetic resonance imaging; PPD; area under receiving operating curve; MRS; SD; Data Coordinating Committee; non-invasive; NPV; Farnesoid X Receptor Ligand Obeticholic Acid in NASH Treatment Trial; DICOM; receiver operating characteristic; BMI; direct comparison; end of treatment; TE; repeat time; Radiology Coordinating Center; region of interest; confidence interval; TR

We assessed the diagnostic performance of magnetic resonance imaging (MRI) proton density fat fraction (PDFF) in grading hepatic steatosis and change in hepatic steatosis in adults with nonalcoholic steatohepatitis (NASH) in a multi-center study, using central histology as reference. We collected da...