Protein expression of targets of the FMRP regulon is altered in brains of subjects with schizophrenia and mood disorders

• Published in: Schizophrenia research Vol. 165; no. 2-3; pp. 201 - 211
• Main Authors: Folsom, Timothy D., Thuras, Paul D., Fatemi, S. Hossein
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2015
• Subjects: Adult; Aged; Aged, 80 and over; Analysis of Variance; APP; bipolar disorder; Brain - metabolism; Cohort Studies; Female; Fragile X Mental Retardation Protein - genetics; Fragile X Mental Retardation Protein - metabolism; homer 1; Humans; Male; Middle Aged; Molecular Weight; Mood Disorders - pathology; Phosphopyruvate Hydratase - metabolism; Presenilin-1 - genetics; Presenilin-1 - metabolism; Protein Tyrosine Phosphatases - genetics; Protein Tyrosine Phosphatases - metabolism; Psychiatry; RAC1; Receptor, Metabotropic Glutamate 5 - genetics; Receptor, Metabotropic Glutamate 5 - metabolism; Regulon - genetics; RNA, Messenger - metabolism; schizophrenia; Schizophrenia - pathology; Signal Transduction - physiology; STEP; APP; bipolar disorder; STEP; schizophrenia; RAC1; homer 1

Fragile X mental retardation protein (FMRP) is an RNA binding protein with 842 target mRNAs in mammalian brain. Silencing of the fragile X mental retardation 1 (FMR1) gene leads to loss of expression of FMRP and upregulated metabotropic glutamate receptor 5 (mGluR5) signaling resulting in the multip...