LncRNA ELF3-AS1 inhibits gastric cancer by forming a negative feedback loop with SNAI2 and regulates ELF3 mRNA stability via interacting with ILF2/ILF3 complex

• Published in: Journal of experimental & clinical cancer research Vol. 41; no. 1; pp. 1 - 17
• Main Authors: Li, Dandan, Shen, Li, Zhang, Xudong, Chen, Zhen, Huang, Pan, Huang, Congcong, Qin, Shanshan
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 02.12.2022; BioMed Central; BMC
• Subjects: Antibodies; Cancer; Cell cycle; Committees; ELF3-AS1; Gastric cancer; Gastric cancer metastasis; Gene expression; Genes; Genetic transcription; Health aspects; Laboratory animals; Medicine; Messenger RNA; Metastasis; MicroRNA; MicroRNAs; mRNA stability; Protein binding; Proteins; Research ethics; RNA sequencing; SNAI2 overexpression; Stomach cancer; Transcription factors; Transcriptional regulation; China; United States > US

Background The biological function of lncRNA ELF3-AS1 remains largely unknown in cancers. The cause of SNAI2 overexpression in tumor metastasis remains largely unclear. The molecular mechanisms underlying the high co-expression of antisense lncRNAs and adjacent protein-coding genes remains unclear....