Long-Acting Thioredoxin Ameliorates Doxorubicin-Induced Cardiomyopathy via Its Anti-Oxidative and Anti-Inflammatory Action

• Published in: Pharmaceutics Vol. 14; no. 3; p. 562
• Main Authors: Murata, Ryota, Watanabe, Hiroshi, Nosaki, Hiroto, Nishida, Kento, Maeda, Hitoshi, Nishida, Motohiro, Maruyama, Toru
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.03.2022; MDPI
• Subjects: albumin fusion; Cardiomyocytes; Cardiomyopathy; Cardiovascular disease; Cytokines; doxorubicin; Experiments; Heart failure; inflammation; Oxidative stress; Pathology; Penicillin; Polyclonal antibodies; thioredoxin; United States > US; Japan; albumin fusion; doxorubicin; cardiomyopathy; inflammation; thioredoxin; oxidative stress

Although the number of patients with heart failure is increasing, a sufficient treatment agent has not been established. Oxidative stress and inflammation play important roles in the development of myocardial remodeling. When thioredoxin (Trx), an endogenous anti-oxidative and inflammatory modulator...