Thermoresponsive magnetic nano-biosensors for rapid measurements of inorganic arsenic and cadmium

Green fluorescent protein-tagged sensor proteins, ArsR-GFP and CadC-GFP, have been produced as biosensors for simple and low-cost quantification of As(III) or Cd(II). In this study, the sensor protein-promoter DNA complexes were reconstructed on the surfaces of magnetic particles of different sizes....

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Published inSensors (Basel, Switzerland) Vol. 12; no. 10; pp. 14041 - 14052
Main Authors Siddiki, Mohammad Shohel Rana, Shimoaoki, Shun, Ueda, Shunsaku, Maeda, Isamu
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 18.10.2012
Molecular Diversity Preservation International (MDPI)
Subjects
Arsenic
Arsenic - analysis
ArsR
Biosensing Techniques - instrumentation
Biosensing Techniques - methods
biosensor
Biosensors
CadC
Cadmium - analysis
Drinking water
Drinking Water - analysis
Environmental Monitoring - instrumentation
Environmental Monitoring - methods
Flocculation
GFP
heavy metal
magnetic nanoparticles
Magnets - chemistry
Nanocomposites
Nanomaterials
Nanoparticles
Nanostructure
Nanostructures - chemistry
Proteins
Sensors
Sperm
Temperature
Time Factors
Water Pollutants, Chemical - analysis
Japan
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Abstract Green fluorescent protein-tagged sensor proteins, ArsR-GFP and CadC-GFP, have been produced as biosensors for simple and low-cost quantification of As(III) or Cd(II). In this study, the sensor protein-promoter DNA complexes were reconstructed on the surfaces of magnetic particles of different sizes. After the surface modification all the particles could be attracted by magnets, and released different amounts of GFP-tagged protein, according to the metal concentrations within 5 min, which caused significant increases in fluorescence. A detection limit of 1 µg/L for As(III) and Cd(II) in purified water was obtained only with the nanoparticles exhibiting enough magnetization after heat treatment for 1 min. Therefore, thermoresponsive magnetic nano-biosensors offer great advantages of rapidity and sensitivity for the measurement of the toxic metals in drinking water.
AbstractList Green fluorescent protein-tagged sensor proteins, ArsR-GFP and CadC-GFP, have been produced as biosensors for simple and low-cost quantification of As(III) or Cd(II). In this study, the sensor protein-promoter DNA complexes were reconstructed on the surfaces of magnetic particles of different sizes. After the surface modification all the particles could be attracted by magnets, and released different amounts of GFP-tagged protein, according to the metal concentrations within 5 min, which caused significant increases in fluorescence. A detection limit of 1 µg/L for As(III) and Cd(II) in purified water was obtained only with the nanoparticles exhibiting enough magnetization after heat treatment for 1 min. Therefore, thermoresponsive magnetic nano-biosensors offer great advantages of rapidity and sensitivity for the measurement of the toxic metals in drinking water.
Green fluorescent protein-tagged sensor proteins, ArsR-GFP and CadC-GFP, have been produced as biosensors for simple and low-cost quantification of As(III) or Cd(II). In this study, the sensor protein-promoter DNA complexes were reconstructed on the surfaces of magnetic particles of different sizes. After the surface modification all the particles could be attracted by magnets, and released different amounts of GFP-tagged protein, according to the metal concentrations within 5 min, which caused significant increases in fluorescence. A detection limit of 1 mu g/L for As(III) and Cd(II) in purified water was obtained only with the nanoparticles exhibiting enough magnetization after heat treatment for 1 min. Therefore, thermoresponsive magnetic nano-biosensors offer great advantages of rapidity and sensitivity for the measurement of the toxic metals in drinking water.
Green fluorescent protein-tagged sensor proteins, ArsR-GFP and CadC-GFP, have been produced as biosensors for simple and low-cost quantification of As(III) or Cd(II). In this study, the sensor protein-promoter DNA complexes were reconstructed on the surfaces of magnetic particles of different sizes. After the surface modification all the particles could be attracted by magnets, and released different amounts of GFP-tagged protein, according to the metal concentrations within 5 min, which caused significant increases in fluorescence. A detection limit of 1 μg/L for As(III) and Cd(II) in purified water was obtained only with the nanoparticles exhibiting enough magnetization after heat treatment for 1 min. Therefore, thermoresponsive magnetic nano-biosensors offer great advantages of rapidity and sensitivity for the measurement of the toxic metals in drinking water.
Author Maeda, Isamu
Siddiki, Mohammad Shohel Rana
Ueda, Shunsaku
Shimoaoki, Shun
AuthorAffiliation 1 United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, 3-5-8 Saiwaicho, Fuchu 183-8509, Japan; E-Mails: msrsiddiki@yahoo.com (M.S.R.S.); uedashun@cc.utsunomiya-u.ac.jp (S.U.)
2 Faculty of Agriculture, Utsunomiya University, 350 Minemachi, Utsunomiya 321-8505, Japan; E-Mail: metal_gear1964@yahoo.co.jp
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2012 by the authors; licensee MDPI, Basel, Switzerland. 2012
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Snippet Green fluorescent protein-tagged sensor proteins, ArsR-GFP and CadC-GFP, have been produced as biosensors for simple and low-cost quantification of As(III) or...
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StartPage 14041
SubjectTerms Arsenic
Arsenic - analysis
ArsR
Biosensing Techniques - instrumentation
Biosensing Techniques - methods
biosensor
Biosensors
CadC
Cadmium - analysis
Drinking water
Drinking Water - analysis
Environmental Monitoring - instrumentation
Environmental Monitoring - methods
Flocculation
GFP
heavy metal
magnetic nanoparticles
Magnets - chemistry
Nanocomposites
Nanomaterials
Nanoparticles
Nanostructure
Nanostructures - chemistry
Proteins
Sensors
Sperm
Temperature
Time Factors
Water Pollutants, Chemical - analysis
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Title Thermoresponsive magnetic nano-biosensors for rapid measurements of inorganic arsenic and cadmium
URI https://www.ncbi.nlm.nih.gov/pubmed/23202034
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https://doaj.org/article/1c10201f44d24a989999e4532de7c816
Volume 12
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