Testis Development and Fertility Potential in Boys with Klinefelter Syndrome
Klinefelter syndrome (KS) is the leading genetic cause of primary hypogonadism and infertility in men. The clinical phenotype has expanded beyond the original description of infertility, small testes, and gynecomastia. Animal models, epidemiologic studies, and clinical research of male subjects with...
Saved in:
| Published in | Endocrinology and metabolism clinics of North America Vol. 44; no. 4; p. 843 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.12.2015
|
| Subjects | |
| Online Access | Get more information |
Cover
Loading…
| Abstract | Klinefelter syndrome (KS) is the leading genetic cause of primary hypogonadism and infertility in men. The clinical phenotype has expanded beyond the original description of infertility, small testes, and gynecomastia. Animal models, epidemiologic studies, and clinical research of male subjects with KS throughout the lifespan have allowed the better characterization of the variable phenotype of this condition. This review provides an overview on what is known of the epidemiology, clinical features, and pathophysiology of KS, followed by a more focused discussion of testicular development and the clinical management of hypogonadism and fertility in boys and men with KS. |
|---|---|
| AbstractList | Klinefelter syndrome (KS) is the leading genetic cause of primary hypogonadism and infertility in men. The clinical phenotype has expanded beyond the original description of infertility, small testes, and gynecomastia. Animal models, epidemiologic studies, and clinical research of male subjects with KS throughout the lifespan have allowed the better characterization of the variable phenotype of this condition. This review provides an overview on what is known of the epidemiology, clinical features, and pathophysiology of KS, followed by a more focused discussion of testicular development and the clinical management of hypogonadism and fertility in boys and men with KS. |
| Author | Rogol, Alan D Davis, Shanlee M Ross, Judith L |
| Author_xml | – sequence: 1 givenname: Shanlee M surname: Davis fullname: Davis, Shanlee M email: Shanlee.Davis@childrenscolorado.org organization: Department of Pediatrics, Children's Hospital Colorado, University of Colorado, 13123 East 16th Avenue, B264, Aurora, CO 80045, USA. Electronic address: Shanlee.Davis@childrenscolorado.org – sequence: 2 givenname: Alan D surname: Rogol fullname: Rogol, Alan D organization: Department of Pediatrics, University of Virginia, 685 Explorers Road, Charlottesville, VA 22911, USA – sequence: 3 givenname: Judith L surname: Ross fullname: Ross, Judith L organization: Department of Pediatric Endocrinology, A.I. DuPont Hospital for Children, 1600 Rockland Road, Wilmington, DE 19803, USA; Department of Pediatrics, Thomas Jefferson University, 833 Chestnut Street, Philadelphia, PA 19107, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26568497$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1j81KxDAUhYMozo8-gBvJC7TepE2aLHWcUbGg4Lge0vYGM6RpaaPSt7egrg6c7_DBWZHT0AUk5IpByoDJm2OKtU85MJFCkQKoE7JkQqgkzxksyGocjzBDUPycLLgUUuW6WJJyj2N0I73HL_Rd32KI1ISG7nCIzrs40dcuzqUznrpA77pppN8uftBn7wJa9BEH-jaFZuhavCBn1vgRL_9yTd532_3mMSlfHp42t2VSi4LFxIBGoytogFe10axiQlptbSV0lQlezCuVKYVMmEZzJW0uWKOgyBDrTEnG1-T619t_Vi02h35wrRmmw_8t_gNqRlBI |
| CitedBy_id | crossref_primary_10_3390_life12010010 crossref_primary_10_1016_j_sxmr_2018_02_008 crossref_primary_10_1002_ajmg_c_31786 crossref_primary_10_1111_andr_12909 crossref_primary_10_1097_GCO_0000000000000612 crossref_primary_10_12688_f1000research_8395_1 crossref_primary_10_1002_bdrc_21147 crossref_primary_10_1186_s13052_018_0485_x crossref_primary_10_1210_js_2019_00274 crossref_primary_10_1016_j_advms_2019_10_004 crossref_primary_10_1016_j_scr_2020_101704 crossref_primary_10_1111_and_14588 crossref_primary_10_12688_f1000research_16747_1 crossref_primary_10_1186_s13039_020_00521_2 crossref_primary_10_1007_s12687_023_00682_8 crossref_primary_10_1002_rmb2_12261 crossref_primary_10_1136_archdischild_2020_320831 crossref_primary_10_1093_humrep_dew179 crossref_primary_10_1097_JCMA_0000000000000603 crossref_primary_10_1002_ajmg_c_31807 crossref_primary_10_3389_fmolb_2023_1128739 crossref_primary_10_1016_j_jpsychores_2016_03_005 crossref_primary_10_1016_j_yapd_2016_04_020 crossref_primary_10_1016_j_mam_2024_101320 crossref_primary_10_1111_jne_13050 crossref_primary_10_1016_j_med_2018_08_002 crossref_primary_10_1080_15265161_2022_2110976 crossref_primary_10_3389_frcha_2024_1356802 crossref_primary_10_1038_s41443_022_00634_9 crossref_primary_10_1038_s41598_017_13528_4 crossref_primary_10_1111_cen_14734 crossref_primary_10_1111_and_13489 crossref_primary_10_1111_andr_12208 crossref_primary_10_51847_GrHPjQ9TYY crossref_primary_10_1016_j_jpeds_2017_02_036 crossref_primary_10_1097_MED_0000000000000454 crossref_primary_10_1002_rmb2_12092 crossref_primary_10_5124_jkma_2020_63_9_548 crossref_primary_10_1186_s12887_024_04723_0 crossref_primary_10_1016_j_fertnstert_2020_01_003 crossref_primary_10_3389_fendo_2022_854186 crossref_primary_10_1007_s00431_021_04083_2 crossref_primary_10_1016_S2213_8587_16_30040_7 crossref_primary_10_3389_fendo_2019_00906 crossref_primary_10_1210_jc_2018_00682 crossref_primary_10_3390_ijms22063264 crossref_primary_10_1016_j_coemr_2019_04_005 |
| ContentType | Journal Article |
| Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: Copyright © 2015 Elsevier Inc. All rights reserved. |
| DBID | CGR CUY CVF ECM EIF NPM |
| DOI | 10.1016/j.ecl.2015.07.008 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
| DatabaseTitleList | MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1558-4410 |
| ExternalDocumentID | 26568497 |
| Genre | Journal Article Review |
| GrantInformation_xml | – fundername: NIDDK NIH HHS grantid: T32 DK063687 – fundername: NINDS NIH HHS grantid: R01 NS050597 |
| GroupedDBID | --- .1- .FO .GJ 0R~ 1CY 1P~ 34G 39C 4.4 457 53G 5GY 5RE 6PF AAEDT AAEDW AALRI AAQQT AAQXK AAWTL AAXUO ABFRF ABMAC ABOCM ABQZK ABWVN ACGFO ACRPL ADBBV ADMUD ADNMO AEFWE AENEX AEVXI AFFNX AFRHN AFTJW AGQPQ AI. AJUYK ALMA_UNASSIGNED_HOLDINGS AMRAJ APXCP ASPBG AVWKF AXIYT AZFZN B08 CGR COIAO CS3 CUY CVF DAHGL DU5 EBS ECM EIF EJD EX3 F5P FDB FEDTE FGOYB HVGLF HZ~ J5H L7B N4W NPM O9- OB0 ON- P2P R2- SEL SES UNMZH VH1 WH7 WOW Z5R ZGI ZXP |
| ID | FETCH-LOGICAL-c571t-a09ea9b0d02bca91b156f9ffb59b3527c578388e15ad9286f451d8073eec38612 |
| IngestDate | Mon Apr 14 02:25:46 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | Klinefelter syndrome Testis development Spermatogenesis X-chromosome Testicular function Reproductive options Sex chromosome aneuploidy |
| Language | English |
| License | Copyright © 2015 Elsevier Inc. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c571t-a09ea9b0d02bca91b156f9ffb59b3527c578388e15ad9286f451d8073eec38612 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/4648691 |
| PMID | 26568497 |
| ParticipantIDs | pubmed_primary_26568497 |
| PublicationCentury | 2000 |
| PublicationDate | 2015-12-01 |
| PublicationDateYYYYMMDD | 2015-12-01 |
| PublicationDate_xml | – month: 12 year: 2015 text: 2015-12-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Endocrinology and metabolism clinics of North America |
| PublicationTitleAlternate | Endocrinol Metab Clin North Am |
| PublicationYear | 2015 |
| SSID | ssj0015082 |
| Score | 2.3720062 |
| SecondaryResourceType | review_article |
| Snippet | Klinefelter syndrome (KS) is the leading genetic cause of primary hypogonadism and infertility in men. The clinical phenotype has expanded beyond the original... |
| SourceID | pubmed |
| SourceType | Index Database |
| StartPage | 843 |
| SubjectTerms | Humans Infertility, Male - etiology Klinefelter Syndrome - complications Male Testis - growth & development |
| Title | Testis Development and Fertility Potential in Boys with Klinefelter Syndrome |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/26568497 |
| Volume | 44 |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT8JAEN6AJsaL8f02e_BGStrSx_aICiEqxggk3Ei33fURaEmsifrrnX2UVkSjXhqyC6TpfDv9ZmfmW4ROPdOxKPAGIzRZw4A3BDWC2OQGDxn14X0UO7JdrHvjdQbO5dAdViqvpaqll4zWo_eFfSX_sSqMgV1Fl-wfLDv7UxiAz2BfuIKF4fo7GwuJjOdy4Y_MBbRFrbSk17dpJqqBpLBG7Sx9071sV4JbciYS5bXeAsmCVhKn4E2SQp9pwjJAy1icqKF6KWUFyKekT7HnrXULeg-h0OEv9lvv0nt1nldzDF7lohhWB7erBhHdBqE3Iiy3VNTBtPN0iQH0yix7V6XuqFHklFwlUfJMX1y42k14qrNIZIYsV2qrSu2HrGTS6UTa1AY6ShxV4fvz7Jyqdj5VRVWIL8SBqWKXR2efgLTaeQZc1gLO3YtQkNa_n4tGJCvpr6M1HU7gpsLGBqqwZBOtdHXBxBa6VhDBJYhgsCeeQQTPIIIfEywgggVEcAkiOIfINhq0W_3zjqEP0DAi17cyWH8BCwNqxqZNozCwKATrPOCcugEF4u3Dt0iDEGa5YRzYxOOOa8UEnD5jUYMA991BS0masD2ECfcZj7wQ6LTvcM-icWTGQcOEJU1E1LuPdtVzGE2VSsoof0IH384cotUCR0domcOyZMfA8TJ6Ig3yAZ7vUmM |
| linkProvider | National Library of Medicine |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Testis+Development+and+Fertility+Potential+in+Boys+with+Klinefelter+Syndrome&rft.jtitle=Endocrinology+and+metabolism+clinics+of+North+America&rft.au=Davis%2C+Shanlee+M&rft.au=Rogol%2C+Alan+D&rft.au=Ross%2C+Judith+L&rft.date=2015-12-01&rft.eissn=1558-4410&rft.volume=44&rft.issue=4&rft.spage=843&rft_id=info:doi/10.1016%2Fj.ecl.2015.07.008&rft_id=info%3Apmid%2F26568497&rft_id=info%3Apmid%2F26568497&rft.externalDocID=26568497 |