Distinguishing severe asthma phenotypes: Role of age at onset and eosinophilic inflammation

• Published in: Journal of allergy and clinical immunology Vol. 113; no. 1; pp. 101 - 108
• Main Authors: Miranda, Christina, Busacker, Ashley, Balzar, Silvana, Trudeau, John, Wenzel, Sally E.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 2004; Elsevier; Elsevier Limited
• Subjects: Age of Onset; Airway management; Allergic diseases; Allergies; allergy; Asthma; Asthma - diagnosis; Biological and medical sciences; Cell Count; Chronic obstructive pulmonary disease, asthma; Cross-Sectional Studies; Disease; Eosinophils - immunology; Female; Humans; Immunopathology; Immunophenotyping; inflammation; Male; Medical sciences; phenotypes; Pneumology; Questionnaires; remodeling; Respiratory and ent allergic diseases; Respiratory Function Tests; Severity of Illness Index; Steroids; Studies; remodeling; phenotypes; PPU; inflammation; LT; allergy; BAL; Asthma; SBM; Human; Lung disease; Respiratory disease; Granulocyte; Clinical form; Inflammation; Remodeling; Eosinophil; Phenotype; Age of onset; Bronchus disease; Obstructive pulmonary disease

Asthma is a heterogeneous process, yet little is understood regarding phenotypes. To determine whether phenotypic differences exist between early-onset, severe asthma as compared with late-onset disease and whether the presence or absence of eosinophilia influences the phenotypes. Cross-sectional an...