Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy

• Published in: Cell death and differentiation Vol. 18; no. 6; pp. 1046 - 1056
• Main Authors: Lu, W-J, Lee, N P, Kaul, S C, Lan, F, Poon, R T P, Wadhwa, R, Luk, J M
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2011; Nature Publishing Group
• Subjects: 631/80/82/23; 692/699/67/1059/602; 692/699/67/1504/1610; Apoptosis; Biochemistry; Biomedical and Life Sciences; Cancer therapies; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Cell Biology; Cell cycle; Cell Cycle Analysis; Cell death; Heat shock proteins; Hep G2 Cells; Hepatocytes - metabolism; HSP70 Heat-Shock Proteins - antagonists & inhibitors; HSP70 Heat-Shock Proteins - metabolism; Humans; Life Sciences; Liver cancer; Mutation; Original Paper; Peptides - pharmacology; Stem Cells; Stress, Physiological; Transcription, Genetic - genetics; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Japan; Singapore; stress; mortalin–p53 interaction; cancer; therapy; target

Stress protein mortalin is a multifunctional protein and is highly expressed in cancers. It has been shown to interact with tumor suppressor protein-p53 (both wild and mutant types) and inactivates its transcriptional activation and apoptotic functions in cancer cells. In the present study, we found...