Withdrawn/Depressed Behaviors and Error-Related Brain Activity in Youth With Obsessive-Compulsive Disorder

• Published in: Journal of the American Academy of Child and Adolescent Psychiatry Vol. 55; no. 10; pp. 906 - 913.e2
• Main Authors: Hanna, Gregory L., MD, Liu, Yanni, PhD, Isaacs, Yona E., BS, Ayoub, Angela M., MSW, Torres, Jose J., MS, O’Hara, Nolan B., MS, Gehring, William J., PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2016; Elsevier BV
• Subjects: Accuracy; Adolescent; Anxiety Disorders; Behavior; Behavior Rating Scales; biomarker; Brain; Brain - physiopathology; Brain activity; Check Lists; Checklists; Child; Child Behavior; Child Behavior Checklist; Child Behaviour Checklist; Childhood; Children; Circuits; Comorbidity; Cortex; Cortex (cingulate); Depression - physiopathology; Depression - psychology; Electroencephalography - methods; error-related negativity; Errors; Evoked Potentials - physiology; Female; Humans; Internalization; Male; Medical diagnosis; Mental depression; Mismatch negativity; Multiple Regression Analysis; Obsessive compulsive disorder; Obsessive-Compulsive Disorder - diagnosis; Obsessive-Compulsive Disorder - physiopathology; Obsessive-Compulsive Disorder - psychology; Pathophysiology; Patients; Pediatrics; Psychiatry; Psychomotor Performance - physiology; Reaction Time - physiology; Regression analysis; Severity; symptom dimensions; Youth; error-related negativity; Child Behavior Checklist; symptom dimensions; biomarker; obsessive-compulsive disorder

Abstract Objective The pathophysiology of obsessive-compulsive disorder (OCD) involves increased activity in cortico-striatal circuits connecting the anterior cingulate cortex (ACC) with other brain regions. The error-related negativity (ERN) is a negative deflection in the event-related potential f...