Withdrawn/Depressed Behaviors and Error-Related Brain Activity in Youth With Obsessive-Compulsive Disorder

Abstract Objective The pathophysiology of obsessive-compulsive disorder (OCD) involves increased activity in cortico-striatal circuits connecting the anterior cingulate cortex (ACC) with other brain regions. The error-related negativity (ERN) is a negative deflection in the event-related potential f...

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Published inJournal of the American Academy of Child and Adolescent Psychiatry Vol. 55; no. 10; pp. 906 - 913.e2
Main Authors Hanna, Gregory L., MD, Liu, Yanni, PhD, Isaacs, Yona E., BS, Ayoub, Angela M., MSW, Torres, Jose J., MS, O’Hara, Nolan B., MS, Gehring, William J., PhD
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.10.2016
Elsevier BV
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Abstract Abstract Objective The pathophysiology of obsessive-compulsive disorder (OCD) involves increased activity in cortico-striatal circuits connecting the anterior cingulate cortex (ACC) with other brain regions. The error-related negativity (ERN) is a negative deflection in the event-related potential following an incorrect response that is thought to reflect ACC activity. This study examined the relationship of the ERN to OCD symptom dimensions and other childhood symptom dimensions. Method The ERN, correct response negativity, and accuracy were measured during a flanker task to assess performance monitoring in 80 youth with a lifetime diagnosis of OCD and 80 matched healthy comparison participants ranging in age from 8 to 18 years. The relationship of the ERN to OCD symptom dimension scores and Child Behavior Checklist (CBCL) Syndrome Scale scores was examined in multiple linear regression analyses. Results Accuracy was significantly decreased and ERN amplitude significantly increased in patients compared with controls. ERN amplitude in patients was significantly correlated with accuracy, but not with OCD symptom dimensions, severity, comorbidity, or treatment. In a multiple linear regression analysis using age, accuracy, OCD, and CBCL Syndrome Scale scores as predictors of ERN amplitude, the ERN had significant associations only with Withdrawn/Depressed Scale scores and accuracy. Conclusion An enlarged ERN is a neural correlate of pediatric OCD that is independent of OCD symptom expression and severity. The finding of lower accuracy in pediatric cases requires replication. The relationship between an enhanced ERN and withdrawn/depressed behaviors warrants further research in youth with OCD and other internalizing disorders.
AbstractList The pathophysiology of obsessive-compulsive disorder (OCD) involves increased activity in corticostriatal circuits connecting the anterior cingulate cortex with other brain regions. The error-related negativity (ERN) is a negative deflection in the event-related potential after an incorrect response that is believed to reflect anterior cingulate cortex activity. This study examined the relation of the ERN to OCD symptom dimensions and other childhood symptom dimensions. The ERN, correct response negativity, and accuracy were measured during a flanker task to assess performance monitoring in 80 youth with a lifetime diagnosis of OCD and 80 matched healthy comparison participants ranging from 8 to 18 years old. The relation of the ERN to OCD symptom dimension scores and Child Behavior Checklist Syndrome Scale scores was examined in multiple linear regression analyses. Accuracy was significantly decreased and ERN amplitude was significantly increased in patients compared with controls. ERN amplitude in patients was significantly correlated with accuracy, but not with OCD symptom dimensions, severity, comorbidity, or treatment. In a multiple linear regression analysis using age, accuracy, OCD, and Child Behavior Checklist Syndrome Scale scores as predictors of ERN amplitude, the ERN had significant associations only with Withdrawn/Depressed Scale scores and accuracy. An enlarged ERN is a neural correlate of pediatric OCD that is independent of OCD symptom expression and severity. The finding of lower accuracy in pediatric cases requires replication. The relation between an enhanced ERN and withdrawn/depressed behaviors warrants further research in youth with OCD and other internalizing disorders.
Abstract Objective The pathophysiology of obsessive-compulsive disorder (OCD) involves increased activity in cortico-striatal circuits connecting the anterior cingulate cortex (ACC) with other brain regions. The error-related negativity (ERN) is a negative deflection in the event-related potential following an incorrect response that is thought to reflect ACC activity. This study examined the relationship of the ERN to OCD symptom dimensions and other childhood symptom dimensions. Method The ERN, correct response negativity, and accuracy were measured during a flanker task to assess performance monitoring in 80 youth with a lifetime diagnosis of OCD and 80 matched healthy comparison participants ranging in age from 8 to 18 years. The relationship of the ERN to OCD symptom dimension scores and Child Behavior Checklist (CBCL) Syndrome Scale scores was examined in multiple linear regression analyses. Results Accuracy was significantly decreased and ERN amplitude significantly increased in patients compared with controls. ERN amplitude in patients was significantly correlated with accuracy, but not with OCD symptom dimensions, severity, comorbidity, or treatment. In a multiple linear regression analysis using age, accuracy, OCD, and CBCL Syndrome Scale scores as predictors of ERN amplitude, the ERN had significant associations only with Withdrawn/Depressed Scale scores and accuracy. Conclusion An enlarged ERN is a neural correlate of pediatric OCD that is independent of OCD symptom expression and severity. The finding of lower accuracy in pediatric cases requires replication. The relationship between an enhanced ERN and withdrawn/depressed behaviors warrants further research in youth with OCD and other internalizing disorders.
OBJECTIVEThe pathophysiology of obsessive-compulsive disorder (OCD) involves increased activity in corticostriatal circuits connecting the anterior cingulate cortex with other brain regions. The error-related negativity (ERN) is a negative deflection in the event-related potential after an incorrect response that is believed to reflect anterior cingulate cortex activity. This study examined the relation of the ERN to OCD symptom dimensions and other childhood symptom dimensions.METHODThe ERN, correct response negativity, and accuracy were measured during a flanker task to assess performance monitoring in 80 youth with a lifetime diagnosis of OCD and 80 matched healthy comparison participants ranging from 8 to 18 years old. The relation of the ERN to OCD symptom dimension scores and Child Behavior Checklist Syndrome Scale scores was examined in multiple linear regression analyses.RESULTSAccuracy was significantly decreased and ERN amplitude was significantly increased in patients compared with controls. ERN amplitude in patients was significantly correlated with accuracy, but not with OCD symptom dimensions, severity, comorbidity, or treatment. In a multiple linear regression analysis using age, accuracy, OCD, and Child Behavior Checklist Syndrome Scale scores as predictors of ERN amplitude, the ERN had significant associations only with Withdrawn/Depressed Scale scores and accuracy.CONCLUSIONAn enlarged ERN is a neural correlate of pediatric OCD that is independent of OCD symptom expression and severity. The finding of lower accuracy in pediatric cases requires replication. The relation between an enhanced ERN and withdrawn/depressed behaviors warrants further research in youth with OCD and other internalizing disorders.
Objective: The pathophysiology of obsessive-compulsive disorder (OCD) involves increased activity in corticostriatal circuits connecting the anterior cingulate cortex with other brain regions. The error-related negativity (ERN) is a negative deflection in the event-related potential after an incorrect response that is believed to reflect anterior cingulate cortex activity. This study examined the relation of the ERN to OCD symptom dimensions and other childhood symptom dimensions. Method: The ERN, correct response negativity, and accuracy were measured during a flanker task to assess performance monitoring in 80 youth with a lifetime diagnosis of OCD and 80 matched healthy comparison participants ranging from 8 to 18 years old. The relation of the ERN to OCD symptom dimension scores and Child Behavior Checklist Syndrome Scale scores was examined in multiple linear regression analyses. Results: Accuracy was significantly decreased and ERN amplitude was significantly increased in patients compared with controls. ERN amplitude in patients was significantly correlated with accuracy, but not with OCD symptom dimensions, severity, comorbidity, or treatment. In a multiple linear regression analysis using age, accuracy, OCD, and Child Behavior Checklist Syndrome Scale scores as predictors of ERN amplitude, the ERN had significant associations only with Withdrawn/Depressed Scale scores and accuracy. Conclusion: An enlarged ERN is a neural correlate of pediatric OCD that is independent of OCD symptom expression and severity. The finding of lower accuracy in pediatric cases requires replication. The relation between an enhanced ERN and withdrawn/depressed behaviors warrants further research in youth with OCD and other internalizing disorders.
Author Gehring, William J., PhD
Hanna, Gregory L., MD
Ayoub, Angela M., MSW
O’Hara, Nolan B., MS
Torres, Jose J., MS
Liu, Yanni, PhD
Isaacs, Yona E., BS
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Cites_doi 10.1038/sj.mp.4002068
10.1038/mp.2008.94
10.1016/j.biopsycho.2010.02.002
10.1016/j.pnpbp.2010.11.022
10.1016/j.jaac.2012.06.019
10.1007/s10519-008-9213-4
10.1001/archpsyc.62.6.593
10.1037/abn0000012
10.1037/abn0000044
10.1016/j.tics.2011.11.003
10.1016/0010-440X(87)90070-8
10.1002/hbm.22240
10.3758/BF03203267
10.1016/j.jaac.2013.12.019
10.1111/j.1467-9280.1993.tb00586.x
10.1016/0013-4694(91)90062-9
10.1111/psyp.12538
10.1176/appi.ajp.2014.14070886
10.1192/bjp.175.5.444
10.1176/appi.ajp.2010.10030416
10.1007/s00406-014-0499-3
10.1016/0013-4694(83)90135-9
10.1111/j.1469-8986.2008.00664.x
10.1016/j.neubiorev.2014.03.024
10.1002/da.22035
10.1016/j.ijpsycho.2015.02.029
10.1097/00004583-199707000-00021
10.1016/j.neuropsychologia.2007.12.001
10.1007/s10519-010-9339-z
10.1097/00004583-199706000-00023
10.1111/j.1469-7610.2005.01465.x
10.1111/j.1469-7610.2004.00279.x
10.1111/1467-9280.00206
10.1097/00004583-199501000-00009
10.1176/appi.ajp.2007.07010143
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Keywords error-related negativity
Child Behavior Checklist
symptom dimensions
biomarker
obsessive-compulsive disorder
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References Achenbach, Rescorla (bib25) 2001
Kaufman, Birmaher, Brent (bib26) 1997; 36
Gehring, Goss, Coles, Meyer, Donchin (bib8) 1993; 4
Hanna (bib3) 1995; 34
Kovacs (bib31) 1985; 21
Hanna, Carrasco, Harbin (bib23) 2012; 51
Riesel, Kathmann, Endrass (bib6) 2014; 264
Ruscio, Stein, Chiu, Kessler (bib2) 2010; 15
Gehring, Himle, Nisenson (bib14) 2000; 11
Stern, Liu, Gehring (bib16) 2010; 47
Riesel, Endrass, Kaufmann, Kathmann (bib18) 2011; 168
Berument, Rutter, Lord, Pickles, Bailey (bib30) 1999; 175
Anokhin, Golosheykin, Heath (bib11) 2008; 45
Carrasco, Harbin, Nienhuis, Fitzgerald, Gehring, Hanna (bib24) 2013; 30
Xiao, Wang, Zhang (bib19) 2011; 35
Endrass, Riesel, Kathmann, Buhlmann (bib20) 2014; 123
Hoekstra, Bartels, Hudziak, Van Beijsterveldt, Boomsma (bib38) 2008; 38
Weinberg, Dieterich, Riesel (bib12) 2015; 98
Eriksen, Eriksen (bib32) 1974; 16
Endrass, Ullsperger (bib13) 2014; 46
Kessler, Berglund, Demler, Jin, Merikangas, Walters (bib1) 2005; 62
Goodwin, Fergusson, Horwood (bib39) 2004; 45
Liu, Hanna, Carrasco, Gehring, Fitzgerald (bib5) 2014; 35
Hajcak, Franklin, Foa, Simons (bib22) 2008; 165
Hanna (bib27) 2010
Hudziak, Althoff, Stanger (bib29) 2006; 47
Riesel, Endrass, Auerbach, Kathmann (bib21) 2015; 172
Milad, Rauch (bib4) 2012; 16
Endrass, Schuermann, Kaufmann, Spielberg, Kniesche, Kathmann (bib17) 2010; 84
Lahat, Lamm, Chronis-Tuscano, Pine, Henderson, Fox (bib36) 2014; 53
Gratton, Coles, Donchin (bib33) 1983; 54
Pitman (bib35) 1987; 28
Gehring, Liu, Orr, Carp (bib10) 2012
Meyer, Hajcak, Torpey-Newman, Kujawa, Klein (bib37) 2015; 124
Walters, Owen (bib40) 2007; 12
Katerberg, Delucchi, Stewart (bib7) 2010; 40
Falkenstein, Hohnsbein, Hoormann, Blanke (bib9) 1991; 78
Scahill, Riddle, McSwiggin-Hardin (bib28) 1997; 36
Endrass, Klawohn, Schuster, Kathmann (bib15) 2008; 46
Weinberg, Meyer, Hale-Rude (bib34) 2016; 53
22138231 - Trends Cogn Sci. 2012 Jan;16(1):43-51
7860451 - J Am Acad Child Adolesc Psychiatry. 1995 Jan;34(1):19-27
15939837 - Arch Gen Psychiatry. 2005 Jun;62(6):593-602
25746725 - Int J Psychophysiol. 2015 Nov;98 (2 Pt 2):276-299
10789276 - Br J Psychiatry. 1999 Nov;175:444-51
25643204 - J Abnorm Psychol. 2015 May;124(2):266-74
25783756 - Am J Psychiatry. 2015 Jul;172(7):665-73
22917203 - J Am Acad Child Adolesc Psychiatry. 2012 Sep;51(9):902-10
9204677 - J Am Acad Child Adolesc Psychiatry. 1997 Jul;36(7):980-8
9183141 - J Am Acad Child Adolesc Psychiatry. 1997 Jun;36(6):844-52
3608467 - Compr Psychiatry. 1987 Jul-Aug;28(4):334-43
16423147 - J Child Psychol Psychiatry. 2006 Feb;47(2):160-6
20230510 - Psychophysiology. 2010 Sep;47(5):913-20
20361247 - Behav Genet. 2010 Jul;40(4):505-17
15056317 - J Child Psychol Psychiatry. 2004 May;45(4):874-83
18514679 - Neuropsychologia. 2008;46(7):1877-87
17895920 - Mol Psychiatry. 2007 Oct;12(10):886-90
11228836 - Psychol Sci. 2000 Jan;11(1):1-6
17986681 - Am J Psychiatry. 2008 Jan;165(1):116-23
18503487 - Psychophysiology. 2008 Jul;45(4):524-34
24655654 - J Am Acad Child Adolesc Psychiatry. 2014 Apr;53(4):447-55
1712280 - Electroencephalogr Clin Neurophysiol. 1991 Jun;78(6):447-55
4089116 - Psychopharmacol Bull. 1985;21(4):995-8
25286372 - J Abnorm Psychol. 2014 Nov;123(4):705-14
21111024 - Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jan 15;35(1):265-72
18548343 - Behav Genet. 2008 Sep;38(5):447-61
24676800 - Eur Arch Psychiatry Clin Neurosci. 2014 Dec;264(8):707-17
21123314 - Am J Psychiatry. 2011 Mar;168(3):317-24
6187540 - Electroencephalogr Clin Neurophysiol. 1983 Apr;55(4):468-84
18725912 - Mol Psychiatry. 2010 Jan;15(1):53-63
23418104 - Hum Brain Mapp. 2014 Apr;35(4):1143-53
23225541 - Depress Anxiety. 2013 Jan;30(1):39-46
26877129 - Psychophysiology. 2016 Mar;53(3):372-85
24747486 - Neurosci Biobehav Rev. 2014 Oct;46 Pt 1:124-38
20152879 - Biol Psychol. 2010 May;84(2):257-63
Gehring (10.1016/j.jaac.2016.06.012_bib8) 1993; 4
Weinberg (10.1016/j.jaac.2016.06.012_bib12) 2015; 98
Endrass (10.1016/j.jaac.2016.06.012_bib17) 2010; 84
Gratton (10.1016/j.jaac.2016.06.012_bib33) 1983; 54
Stern (10.1016/j.jaac.2016.06.012_bib16) 2010; 47
Goodwin (10.1016/j.jaac.2016.06.012_bib39) 2004; 45
Achenbach (10.1016/j.jaac.2016.06.012_bib25) 2001
Pitman (10.1016/j.jaac.2016.06.012_bib35) 1987; 28
Endrass (10.1016/j.jaac.2016.06.012_bib15) 2008; 46
Anokhin (10.1016/j.jaac.2016.06.012_bib11) 2008; 45
Eriksen (10.1016/j.jaac.2016.06.012_bib32) 1974; 16
Katerberg (10.1016/j.jaac.2016.06.012_bib7) 2010; 40
Kovacs (10.1016/j.jaac.2016.06.012_bib31) 1985; 21
Kaufman (10.1016/j.jaac.2016.06.012_bib26) 1997; 36
Weinberg (10.1016/j.jaac.2016.06.012_bib34) 2016; 53
Gehring (10.1016/j.jaac.2016.06.012_bib10) 2012
Hanna (10.1016/j.jaac.2016.06.012_bib23) 2012; 51
Lahat (10.1016/j.jaac.2016.06.012_bib36) 2014; 53
Hanna (10.1016/j.jaac.2016.06.012_bib27) 2010
Falkenstein (10.1016/j.jaac.2016.06.012_bib9) 1991; 78
Hudziak (10.1016/j.jaac.2016.06.012_bib29) 2006; 47
Hoekstra (10.1016/j.jaac.2016.06.012_bib38) 2008; 38
Kessler (10.1016/j.jaac.2016.06.012_bib1) 2005; 62
Walters (10.1016/j.jaac.2016.06.012_bib40) 2007; 12
Hanna (10.1016/j.jaac.2016.06.012_bib3) 1995; 34
Meyer (10.1016/j.jaac.2016.06.012_bib37) 2015; 124
Riesel (10.1016/j.jaac.2016.06.012_bib6) 2014; 264
Riesel (10.1016/j.jaac.2016.06.012_bib21) 2015; 172
Berument (10.1016/j.jaac.2016.06.012_bib30) 1999; 175
Riesel (10.1016/j.jaac.2016.06.012_bib18) 2011; 168
Carrasco (10.1016/j.jaac.2016.06.012_bib24) 2013; 30
Ruscio (10.1016/j.jaac.2016.06.012_bib2) 2010; 15
Scahill (10.1016/j.jaac.2016.06.012_bib28) 1997; 36
Xiao (10.1016/j.jaac.2016.06.012_bib19) 2011; 35
Liu (10.1016/j.jaac.2016.06.012_bib5) 2014; 35
Hajcak (10.1016/j.jaac.2016.06.012_bib22) 2008; 165
Milad (10.1016/j.jaac.2016.06.012_bib4) 2012; 16
Gehring (10.1016/j.jaac.2016.06.012_bib14) 2000; 11
Endrass (10.1016/j.jaac.2016.06.012_bib20) 2014; 123
Endrass (10.1016/j.jaac.2016.06.012_bib13) 2014; 46
References_xml – volume: 28
  start-page: 334
  year: 1987
  end-page: 343
  ident: bib35
  article-title: A cybernetic model of obsessive-compulsive psychopathology
  publication-title: Compr Psychiatry
  contributor:
    fullname: Pitman
– volume: 47
  start-page: 160
  year: 2006
  end-page: 166
  ident: bib29
  article-title: The Obsessive Compulsive Scale of the Child Behavior Checklist predicts obsessive-compulsive disorder: a receiver operating characteristic curve analysis
  publication-title: J Child Psychol Psychiatry
  contributor:
    fullname: Stanger
– volume: 46
  start-page: 124
  year: 2014
  end-page: 138
  ident: bib13
  article-title: Specificity of performance monitoring changes in obsessive-compulsive disorder
  publication-title: Neurosci Biobehavior Rev
  contributor:
    fullname: Ullsperger
– volume: 46
  start-page: 1877
  year: 2008
  end-page: 1887
  ident: bib15
  article-title: Overactive performance monitoring in obsessive-compulsive disorder: ERP evidence from correct and erroneous reactions
  publication-title: Neuropsychologia
  contributor:
    fullname: Kathmann
– volume: 45
  start-page: 524
  year: 2008
  end-page: 534
  ident: bib11
  article-title: Heritability of frontal brain function related to action monitoring
  publication-title: Psychophysiology
  contributor:
    fullname: Heath
– volume: 38
  start-page: 447
  year: 2008
  end-page: 461
  ident: bib38
  article-title: Genetic and environmental influences on the stability of withdrawn behavior in children: a longitudinal multi-informant twin study
  publication-title: Behav Genet
  contributor:
    fullname: Boomsma
– volume: 78
  start-page: 447
  year: 1991
  end-page: 455
  ident: bib9
  article-title: Effects of crossmodal divided attention on late ERP components, II: error processing in choice reaction tasks
  publication-title: Electroencephalogr Clin Neurophysiol
  contributor:
    fullname: Blanke
– volume: 16
  start-page: 43
  year: 2012
  end-page: 51
  ident: bib4
  article-title: Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways
  publication-title: Trends Cogn Sci
  contributor:
    fullname: Rauch
– volume: 84
  start-page: 257
  year: 2010
  end-page: 263
  ident: bib17
  article-title: Performance monitoring and error significance in patients with obsessive-compulsive disorder
  publication-title: Biol Psychol
  contributor:
    fullname: Kathmann
– volume: 21
  start-page: 995
  year: 1985
  end-page: 998
  ident: bib31
  article-title: The Children’s Depression Inventory (CDI)
  publication-title: Psychopharm Bull
  contributor:
    fullname: Kovacs
– volume: 62
  start-page: 593
  year: 2005
  end-page: 602
  ident: bib1
  article-title: Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication
  publication-title: Arch Gen Psychiatry
  contributor:
    fullname: Walters
– year: 2001
  ident: bib25
  article-title: Manual for ASEBA School-Age Forms and Profiles
  contributor:
    fullname: Rescorla
– volume: 45
  start-page: 874
  year: 2004
  end-page: 883
  ident: bib39
  article-title: Early anxious/withdrawn behaviours predict later internalising disorders
  publication-title: J Child Psychol Psychiatry
  contributor:
    fullname: Horwood
– volume: 15
  start-page: 53
  year: 2010
  end-page: 63
  ident: bib2
  article-title: The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication
  publication-title: Mol Psychiatry
  contributor:
    fullname: Kessler
– volume: 35
  start-page: 1143
  year: 2014
  end-page: 1153
  ident: bib5
  article-title: Altered relationship between electrophysiological response to errors and gray matter volumes in an extended network for error processing in pediatric obsessive-compulsive disorder
  publication-title: Hum Brain Mapp
  contributor:
    fullname: Fitzgerald
– volume: 36
  start-page: 980
  year: 1997
  end-page: 988
  ident: bib26
  article-title: Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data
  publication-title: J Am Acad Child Adolesc Psychiatry
  contributor:
    fullname: Brent
– volume: 47
  start-page: 913
  year: 2010
  end-page: 920
  ident: bib16
  article-title: Chronic medication does not affect hyperactive error responses in obsessive-compulsive disorder
  publication-title: Psychophysiology
  contributor:
    fullname: Gehring
– volume: 34
  start-page: 19
  year: 1995
  end-page: 27
  ident: bib3
  article-title: Demographic and clinical features of obsessive-compulsive disorder in children and adolescents
  publication-title: J Am Acad Child Adolesc Psychiatry
  contributor:
    fullname: Hanna
– volume: 51
  start-page: 902
  year: 2012
  end-page: 910
  ident: bib23
  article-title: Error-related negativity and tic history in pediatric obsessive-compulsive disorder
  publication-title: J Am Acad Child Adolesc Psychiatry
  contributor:
    fullname: Harbin
– volume: 54
  start-page: 468
  year: 1983
  end-page: 484
  ident: bib33
  article-title: A new method for off-line removal of ocular artifact
  publication-title: Electroencephalogr Clin Neurophysiol
  contributor:
    fullname: Donchin
– volume: 123
  start-page: 705
  year: 2014
  end-page: 714
  ident: bib20
  article-title: Performance monitoring in obsessive-compulsive disorder and social anxiety disorder
  publication-title: J Abnorm Psychol
  contributor:
    fullname: Buhlmann
– volume: 53
  start-page: 447
  year: 2014
  end-page: 455
  ident: bib36
  article-title: Early behavioral inhibition and increased error monitoring predict later social phobia symptoms in childhood
  publication-title: J Am Acad Child Adolesc Psychiatry
  contributor:
    fullname: Fox
– volume: 30
  start-page: 39
  year: 2013
  end-page: 46
  ident: bib24
  article-title: Increased error-related brain activity in youth with obsessive-compulsive disorder and unaffected siblings
  publication-title: Depress Anxiety
  contributor:
    fullname: Hanna
– volume: 53
  start-page: 372
  year: 2016
  end-page: 385
  ident: bib34
  article-title: Error-related negativity and sustained threat: conceptual framework and empirical evaluation in an adolescent sample
  publication-title: Psychophysiology
  contributor:
    fullname: Hale-Rude
– volume: 11
  start-page: 1
  year: 2000
  end-page: 6
  ident: bib14
  article-title: Action-monitoring dysfunction in obsessive-compulsive disorder
  publication-title: Psychol Sci
  contributor:
    fullname: Nisenson
– volume: 172
  start-page: 665
  year: 2015
  end-page: 673
  ident: bib21
  article-title: Overactive performance monitoring as an endophenotype for obsessive-compulsive disorder: evidence from a treatment study
  publication-title: Am J Psychiatry
  contributor:
    fullname: Kathmann
– volume: 16
  start-page: 143
  year: 1974
  end-page: 149
  ident: bib32
  article-title: Effects of noise letters upon the identification of a target letter in a non-search task
  publication-title: Percept Psychophysiol
  contributor:
    fullname: Eriksen
– volume: 12
  start-page: 886
  year: 2007
  end-page: 890
  ident: bib40
  article-title: Endophenotypes in psychiatric genetics
  publication-title: Mol Psychiatry
  contributor:
    fullname: Owen
– volume: 40
  start-page: 505
  year: 2010
  end-page: 517
  ident: bib7
  article-title: Symptom dimensions in OCD: item-level factor analysis and heritability estimates
  publication-title: Behav Genet
  contributor:
    fullname: Stewart
– volume: 124
  start-page: 266
  year: 2015
  end-page: 274
  ident: bib37
  article-title: Enhanced error-related brain activity in children predicts the onset of anxiety disorders between the ages of 6 and 9
  publication-title: J Abnorm Psychol
  contributor:
    fullname: Klein
– volume: 168
  start-page: 317
  year: 2011
  end-page: 324
  ident: bib18
  article-title: Overactive error-related brain activity as a candidate endophenotype for obsessive-compulsive disorder: evidence from unaffected first-degree relatives
  publication-title: Am J Psychiatry
  contributor:
    fullname: Kathmann
– start-page: 231
  year: 2012
  end-page: 291
  ident: bib10
  article-title: The error-related negativity (ERN/Ne)
  publication-title: Oxford Handbook of Event-Related Potential Components
  contributor:
    fullname: Carp
– volume: 165
  start-page: 116
  year: 2008
  end-page: 123
  ident: bib22
  article-title: Increased error-related brain activity in pediatric OCD before and after treatment
  publication-title: Am J Psychiatry
  contributor:
    fullname: Simons
– volume: 175
  start-page: 444
  year: 1999
  end-page: 451
  ident: bib30
  article-title: Autism screening questionnaire: diagnostic validity
  publication-title: Br J Psychiatry
  contributor:
    fullname: Bailey
– volume: 4
  start-page: 385
  year: 1993
  end-page: 390
  ident: bib8
  article-title: A neural system for error detection and compensation
  publication-title: Psychol Sci
  contributor:
    fullname: Donchin
– year: 2010
  ident: bib27
  article-title: Schedule for Obsessive-Compulsive and Other Behavioral Syndromes (SOCOBS)
  contributor:
    fullname: Hanna
– volume: 98
  start-page: 276
  year: 2015
  end-page: 299
  ident: bib12
  article-title: Error-related brain activity in the age of RDoC: a review of the literature
  publication-title: Int J Psychophysiology
  contributor:
    fullname: Riesel
– volume: 264
  start-page: 707
  year: 2014
  end-page: 717
  ident: bib6
  article-title: Overactive performance monitoring in obsessive-compulsive disorder is independent of symptom expression
  publication-title: Eur Arch Psychiatry Clin Neurosci
  contributor:
    fullname: Endrass
– volume: 35
  start-page: 265
  year: 2011
  end-page: 272
  ident: bib19
  article-title: Error-related negativity abnormalities in generalized anxiety disorder and obsessive-compulsive disorder
  publication-title: Prog Neuropsychopharm Biol Psychiatry
  contributor:
    fullname: Zhang
– volume: 36
  start-page: 844
  year: 1997
  end-page: 852
  ident: bib28
  article-title: Children’s Yale-Brown Obsessive Compulsive Scale: reliability and validity
  publication-title: J Am Acad Child Adolesc Psychiatry
  contributor:
    fullname: McSwiggin-Hardin
– volume: 12
  start-page: 886
  year: 2007
  ident: 10.1016/j.jaac.2016.06.012_bib40
  article-title: Endophenotypes in psychiatric genetics
  publication-title: Mol Psychiatry
  doi: 10.1038/sj.mp.4002068
  contributor:
    fullname: Walters
– volume: 15
  start-page: 53
  year: 2010
  ident: 10.1016/j.jaac.2016.06.012_bib2
  article-title: The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2008.94
  contributor:
    fullname: Ruscio
– volume: 84
  start-page: 257
  year: 2010
  ident: 10.1016/j.jaac.2016.06.012_bib17
  article-title: Performance monitoring and error significance in patients with obsessive-compulsive disorder
  publication-title: Biol Psychol
  doi: 10.1016/j.biopsycho.2010.02.002
  contributor:
    fullname: Endrass
– volume: 35
  start-page: 265
  year: 2011
  ident: 10.1016/j.jaac.2016.06.012_bib19
  article-title: Error-related negativity abnormalities in generalized anxiety disorder and obsessive-compulsive disorder
  publication-title: Prog Neuropsychopharm Biol Psychiatry
  doi: 10.1016/j.pnpbp.2010.11.022
  contributor:
    fullname: Xiao
– volume: 51
  start-page: 902
  year: 2012
  ident: 10.1016/j.jaac.2016.06.012_bib23
  article-title: Error-related negativity and tic history in pediatric obsessive-compulsive disorder
  publication-title: J Am Acad Child Adolesc Psychiatry
  doi: 10.1016/j.jaac.2012.06.019
  contributor:
    fullname: Hanna
– volume: 38
  start-page: 447
  year: 2008
  ident: 10.1016/j.jaac.2016.06.012_bib38
  article-title: Genetic and environmental influences on the stability of withdrawn behavior in children: a longitudinal multi-informant twin study
  publication-title: Behav Genet
  doi: 10.1007/s10519-008-9213-4
  contributor:
    fullname: Hoekstra
– volume: 62
  start-page: 593
  year: 2005
  ident: 10.1016/j.jaac.2016.06.012_bib1
  article-title: Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication
  publication-title: Arch Gen Psychiatry
  doi: 10.1001/archpsyc.62.6.593
  contributor:
    fullname: Kessler
– volume: 123
  start-page: 705
  year: 2014
  ident: 10.1016/j.jaac.2016.06.012_bib20
  article-title: Performance monitoring in obsessive-compulsive disorder and social anxiety disorder
  publication-title: J Abnorm Psychol
  doi: 10.1037/abn0000012
  contributor:
    fullname: Endrass
– volume: 124
  start-page: 266
  year: 2015
  ident: 10.1016/j.jaac.2016.06.012_bib37
  article-title: Enhanced error-related brain activity in children predicts the onset of anxiety disorders between the ages of 6 and 9
  publication-title: J Abnorm Psychol
  doi: 10.1037/abn0000044
  contributor:
    fullname: Meyer
– volume: 16
  start-page: 43
  year: 2012
  ident: 10.1016/j.jaac.2016.06.012_bib4
  article-title: Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways
  publication-title: Trends Cogn Sci
  doi: 10.1016/j.tics.2011.11.003
  contributor:
    fullname: Milad
– volume: 28
  start-page: 334
  year: 1987
  ident: 10.1016/j.jaac.2016.06.012_bib35
  article-title: A cybernetic model of obsessive-compulsive psychopathology
  publication-title: Compr Psychiatry
  doi: 10.1016/0010-440X(87)90070-8
  contributor:
    fullname: Pitman
– volume: 35
  start-page: 1143
  year: 2014
  ident: 10.1016/j.jaac.2016.06.012_bib5
  article-title: Altered relationship between electrophysiological response to errors and gray matter volumes in an extended network for error processing in pediatric obsessive-compulsive disorder
  publication-title: Hum Brain Mapp
  doi: 10.1002/hbm.22240
  contributor:
    fullname: Liu
– volume: 16
  start-page: 143
  year: 1974
  ident: 10.1016/j.jaac.2016.06.012_bib32
  article-title: Effects of noise letters upon the identification of a target letter in a non-search task
  publication-title: Percept Psychophysiol
  doi: 10.3758/BF03203267
  contributor:
    fullname: Eriksen
– volume: 53
  start-page: 447
  year: 2014
  ident: 10.1016/j.jaac.2016.06.012_bib36
  article-title: Early behavioral inhibition and increased error monitoring predict later social phobia symptoms in childhood
  publication-title: J Am Acad Child Adolesc Psychiatry
  doi: 10.1016/j.jaac.2013.12.019
  contributor:
    fullname: Lahat
– volume: 4
  start-page: 385
  year: 1993
  ident: 10.1016/j.jaac.2016.06.012_bib8
  article-title: A neural system for error detection and compensation
  publication-title: Psychol Sci
  doi: 10.1111/j.1467-9280.1993.tb00586.x
  contributor:
    fullname: Gehring
– volume: 78
  start-page: 447
  year: 1991
  ident: 10.1016/j.jaac.2016.06.012_bib9
  article-title: Effects of crossmodal divided attention on late ERP components, II: error processing in choice reaction tasks
  publication-title: Electroencephalogr Clin Neurophysiol
  doi: 10.1016/0013-4694(91)90062-9
  contributor:
    fullname: Falkenstein
– volume: 53
  start-page: 372
  year: 2016
  ident: 10.1016/j.jaac.2016.06.012_bib34
  article-title: Error-related negativity and sustained threat: conceptual framework and empirical evaluation in an adolescent sample
  publication-title: Psychophysiology
  doi: 10.1111/psyp.12538
  contributor:
    fullname: Weinberg
– start-page: 231
  year: 2012
  ident: 10.1016/j.jaac.2016.06.012_bib10
  article-title: The error-related negativity (ERN/Ne)
  contributor:
    fullname: Gehring
– volume: 21
  start-page: 995
  year: 1985
  ident: 10.1016/j.jaac.2016.06.012_bib31
  article-title: The Children’s Depression Inventory (CDI)
  publication-title: Psychopharm Bull
  contributor:
    fullname: Kovacs
– volume: 172
  start-page: 665
  year: 2015
  ident: 10.1016/j.jaac.2016.06.012_bib21
  article-title: Overactive performance monitoring as an endophenotype for obsessive-compulsive disorder: evidence from a treatment study
  publication-title: Am J Psychiatry
  doi: 10.1176/appi.ajp.2014.14070886
  contributor:
    fullname: Riesel
– volume: 175
  start-page: 444
  year: 1999
  ident: 10.1016/j.jaac.2016.06.012_bib30
  article-title: Autism screening questionnaire: diagnostic validity
  publication-title: Br J Psychiatry
  doi: 10.1192/bjp.175.5.444
  contributor:
    fullname: Berument
– volume: 168
  start-page: 317
  year: 2011
  ident: 10.1016/j.jaac.2016.06.012_bib18
  article-title: Overactive error-related brain activity as a candidate endophenotype for obsessive-compulsive disorder: evidence from unaffected first-degree relatives
  publication-title: Am J Psychiatry
  doi: 10.1176/appi.ajp.2010.10030416
  contributor:
    fullname: Riesel
– volume: 264
  start-page: 707
  year: 2014
  ident: 10.1016/j.jaac.2016.06.012_bib6
  article-title: Overactive performance monitoring in obsessive-compulsive disorder is independent of symptom expression
  publication-title: Eur Arch Psychiatry Clin Neurosci
  doi: 10.1007/s00406-014-0499-3
  contributor:
    fullname: Riesel
– year: 2010
  ident: 10.1016/j.jaac.2016.06.012_bib27
  contributor:
    fullname: Hanna
– volume: 54
  start-page: 468
  year: 1983
  ident: 10.1016/j.jaac.2016.06.012_bib33
  article-title: A new method for off-line removal of ocular artifact
  publication-title: Electroencephalogr Clin Neurophysiol
  doi: 10.1016/0013-4694(83)90135-9
  contributor:
    fullname: Gratton
– volume: 45
  start-page: 524
  year: 2008
  ident: 10.1016/j.jaac.2016.06.012_bib11
  article-title: Heritability of frontal brain function related to action monitoring
  publication-title: Psychophysiology
  doi: 10.1111/j.1469-8986.2008.00664.x
  contributor:
    fullname: Anokhin
– volume: 46
  start-page: 124
  year: 2014
  ident: 10.1016/j.jaac.2016.06.012_bib13
  article-title: Specificity of performance monitoring changes in obsessive-compulsive disorder
  publication-title: Neurosci Biobehavior Rev
  doi: 10.1016/j.neubiorev.2014.03.024
  contributor:
    fullname: Endrass
– volume: 30
  start-page: 39
  year: 2013
  ident: 10.1016/j.jaac.2016.06.012_bib24
  article-title: Increased error-related brain activity in youth with obsessive-compulsive disorder and unaffected siblings
  publication-title: Depress Anxiety
  doi: 10.1002/da.22035
  contributor:
    fullname: Carrasco
– volume: 98
  start-page: 276
  year: 2015
  ident: 10.1016/j.jaac.2016.06.012_bib12
  article-title: Error-related brain activity in the age of RDoC: a review of the literature
  publication-title: Int J Psychophysiology
  doi: 10.1016/j.ijpsycho.2015.02.029
  contributor:
    fullname: Weinberg
– volume: 36
  start-page: 980
  year: 1997
  ident: 10.1016/j.jaac.2016.06.012_bib26
  article-title: Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data
  publication-title: J Am Acad Child Adolesc Psychiatry
  doi: 10.1097/00004583-199707000-00021
  contributor:
    fullname: Kaufman
– volume: 46
  start-page: 1877
  year: 2008
  ident: 10.1016/j.jaac.2016.06.012_bib15
  article-title: Overactive performance monitoring in obsessive-compulsive disorder: ERP evidence from correct and erroneous reactions
  publication-title: Neuropsychologia
  doi: 10.1016/j.neuropsychologia.2007.12.001
  contributor:
    fullname: Endrass
– year: 2001
  ident: 10.1016/j.jaac.2016.06.012_bib25
  contributor:
    fullname: Achenbach
– volume: 40
  start-page: 505
  year: 2010
  ident: 10.1016/j.jaac.2016.06.012_bib7
  article-title: Symptom dimensions in OCD: item-level factor analysis and heritability estimates
  publication-title: Behav Genet
  doi: 10.1007/s10519-010-9339-z
  contributor:
    fullname: Katerberg
– volume: 36
  start-page: 844
  year: 1997
  ident: 10.1016/j.jaac.2016.06.012_bib28
  article-title: Children’s Yale-Brown Obsessive Compulsive Scale: reliability and validity
  publication-title: J Am Acad Child Adolesc Psychiatry
  doi: 10.1097/00004583-199706000-00023
  contributor:
    fullname: Scahill
– volume: 47
  start-page: 160
  year: 2006
  ident: 10.1016/j.jaac.2016.06.012_bib29
  article-title: The Obsessive Compulsive Scale of the Child Behavior Checklist predicts obsessive-compulsive disorder: a receiver operating characteristic curve analysis
  publication-title: J Child Psychol Psychiatry
  doi: 10.1111/j.1469-7610.2005.01465.x
  contributor:
    fullname: Hudziak
– volume: 47
  start-page: 913
  year: 2010
  ident: 10.1016/j.jaac.2016.06.012_bib16
  article-title: Chronic medication does not affect hyperactive error responses in obsessive-compulsive disorder
  publication-title: Psychophysiology
  contributor:
    fullname: Stern
– volume: 45
  start-page: 874
  year: 2004
  ident: 10.1016/j.jaac.2016.06.012_bib39
  article-title: Early anxious/withdrawn behaviours predict later internalising disorders
  publication-title: J Child Psychol Psychiatry
  doi: 10.1111/j.1469-7610.2004.00279.x
  contributor:
    fullname: Goodwin
– volume: 11
  start-page: 1
  year: 2000
  ident: 10.1016/j.jaac.2016.06.012_bib14
  article-title: Action-monitoring dysfunction in obsessive-compulsive disorder
  publication-title: Psychol Sci
  doi: 10.1111/1467-9280.00206
  contributor:
    fullname: Gehring
– volume: 34
  start-page: 19
  year: 1995
  ident: 10.1016/j.jaac.2016.06.012_bib3
  article-title: Demographic and clinical features of obsessive-compulsive disorder in children and adolescents
  publication-title: J Am Acad Child Adolesc Psychiatry
  doi: 10.1097/00004583-199501000-00009
  contributor:
    fullname: Hanna
– volume: 165
  start-page: 116
  year: 2008
  ident: 10.1016/j.jaac.2016.06.012_bib22
  article-title: Increased error-related brain activity in pediatric OCD before and after treatment
  publication-title: Am J Psychiatry
  doi: 10.1176/appi.ajp.2007.07010143
  contributor:
    fullname: Hajcak
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Snippet Abstract Objective The pathophysiology of obsessive-compulsive disorder (OCD) involves increased activity in cortico-striatal circuits connecting the anterior...
The pathophysiology of obsessive-compulsive disorder (OCD) involves increased activity in corticostriatal circuits connecting the anterior cingulate cortex...
Objective: The pathophysiology of obsessive-compulsive disorder (OCD) involves increased activity in corticostriatal circuits connecting the anterior cingulate...
OBJECTIVEThe pathophysiology of obsessive-compulsive disorder (OCD) involves increased activity in corticostriatal circuits connecting the anterior cingulate...
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SubjectTerms Accuracy
Adolescent
Anxiety Disorders
Behavior
Behavior Rating Scales
biomarker
Brain
Brain - physiopathology
Brain activity
Check Lists
Checklists
Child
Child Behavior
Child Behavior Checklist
Child Behaviour Checklist
Childhood
Children
Circuits
Comorbidity
Cortex
Cortex (cingulate)
Depression - physiopathology
Depression - psychology
Electroencephalography - methods
error-related negativity
Errors
Evoked Potentials - physiology
Female
Humans
Internalization
Male
Medical diagnosis
Mental depression
Mismatch negativity
Multiple Regression Analysis
Obsessive compulsive disorder
Obsessive-Compulsive Disorder - diagnosis
Obsessive-Compulsive Disorder - physiopathology
Obsessive-Compulsive Disorder - psychology
Pathophysiology
Patients
Pediatrics
Psychiatry
Psychomotor Performance - physiology
Reaction Time - physiology
Regression analysis
Severity
symptom dimensions
Youth
Title Withdrawn/Depressed Behaviors and Error-Related Brain Activity in Youth With Obsessive-Compulsive Disorder
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https://dx.doi.org/10.1016/j.jaac.2016.06.012
https://www.ncbi.nlm.nih.gov/pubmed/27663946
https://www.proquest.com/docview/1826417227
https://search.proquest.com/docview/1823031921
https://search.proquest.com/docview/1837343374
https://pubmed.ncbi.nlm.nih.gov/PMC5577943
Volume 55
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