Osteoclasts: more than ‘bone eaters’

• Published in: Trends in molecular medicine Vol. 20; no. 8; pp. 449 - 459
• Main Authors: Charles, Julia F., Aliprantis, Antonios O.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2014
• Subjects: Animals; Bone and Bones - metabolism; Bone and Bones - pathology; Bone Remodeling; Bone Resorption - metabolism; Bone Resorption - pathology; Fibrous Dysplasia of Bone - metabolism; Fibrous Dysplasia of Bone - pathology; Giant Cell Tumor of Bone - metabolism; Giant Cell Tumor of Bone - pathology; Humans; osteoblast; osteoclast; Osteoclasts - cytology; Osteoclasts - metabolism; Osteoclasts - pathology; Osteogenesis; osteopetrosis; Osteopetrosis - metabolism; Osteopetrosis - pathology; osteoporosis; Osteoporosis - metabolism; Osteoporosis - pathology; Pathology; PTH; bone remodeling; osteopetrosis; osteoblast; osteoclast; osteoporosis; PTH

•Osteoclasts modify the skeletal environment beyond their ability to resorb bone.•Bone-forming osteoblasts and their precursors are regulated by osteoclasts.•Cancer, hematopoietic, and immune cells are targets of osteoclast-derived factors.•Insight into the osteoclast may improve outcomes for patien...