Osteoclasts: more than ‘bone eaters’
•Osteoclasts modify the skeletal environment beyond their ability to resorb bone.•Bone-forming osteoblasts and their precursors are regulated by osteoclasts.•Cancer, hematopoietic, and immune cells are targets of osteoclast-derived factors.•Insight into the osteoclast may improve outcomes for patien...
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| Published in | Trends in molecular medicine Vol. 20; no. 8; pp. 449 - 459 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.08.2014
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| Subjects | |
| Online Access | Get full text |
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| Abstract | •Osteoclasts modify the skeletal environment beyond their ability to resorb bone.•Bone-forming osteoblasts and their precursors are regulated by osteoclasts.•Cancer, hematopoietic, and immune cells are targets of osteoclast-derived factors.•Insight into the osteoclast may improve outcomes for patients with bone diseases.
As the only cells definitively shown to degrade bone, osteoclasts are key mediators of skeletal diseases including osteoporosis. Bone-forming osteoblasts, and hematopoietic and immune system cells, each influence osteoclast formation and function, but the reciprocal impact of osteoclasts on these cells is less well appreciated. We highlight here the functions that osteoclasts perform beyond bone resorption. First, we consider how osteoclast signals may contribute to bone formation by osteoblasts and to the pathology of bone lesions such as fibrous dysplasia and giant cell tumors. Second, we review the interaction of osteoclasts with the hematopoietic system, including the stem cell niche and adaptive immune cells. Connections between osteoclasts and other cells in the bone microenvironment are discussed within a clinically relevant framework. |
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| AbstractList | As the only cells definitively shown to degrade bone, osteoclasts are key mediators of skeletal diseases including osteoporosis. Bone forming osteoblasts, and hematopoietic and immune system cells, each influence osteoclast formation and function, but the reciprocal impact of osteoclasts on these cells is less well appreciated. Here, we highlight functions osteoclasts perform beyond bone resorption. First, we consider how osteoclast signals may contribute to bone formation by osteoblasts and the pathology of bone lesions, such as fibrous dysplasia and giant cell tumors. Second, we review the interaction of osteoclasts with the hematopoietic system, including the stem cell niche and adaptive immune cells. Connections between osteoclasts and other cells in the bone microenvironment are discussed within a clinically relevant framework. •Osteoclasts modify the skeletal environment beyond their ability to resorb bone.•Bone-forming osteoblasts and their precursors are regulated by osteoclasts.•Cancer, hematopoietic, and immune cells are targets of osteoclast-derived factors.•Insight into the osteoclast may improve outcomes for patients with bone diseases. As the only cells definitively shown to degrade bone, osteoclasts are key mediators of skeletal diseases including osteoporosis. Bone-forming osteoblasts, and hematopoietic and immune system cells, each influence osteoclast formation and function, but the reciprocal impact of osteoclasts on these cells is less well appreciated. We highlight here the functions that osteoclasts perform beyond bone resorption. First, we consider how osteoclast signals may contribute to bone formation by osteoblasts and to the pathology of bone lesions such as fibrous dysplasia and giant cell tumors. Second, we review the interaction of osteoclasts with the hematopoietic system, including the stem cell niche and adaptive immune cells. Connections between osteoclasts and other cells in the bone microenvironment are discussed within a clinically relevant framework. Highlights • Osteoclasts modify the skeletal environment beyond their ability to resorb bone. • Bone-forming osteoblasts and their precursors are regulated by osteoclasts. • Cancer, hematopoietic, and immune cells are targets of osteoclast-derived factors. • Insight into the osteoclast may improve outcomes for patients with bone diseases. As the only cells definitively shown to degrade bone, osteoclasts are key mediators of skeletal diseases including osteoporosis. Bone-forming osteoblasts, and hematopoietic and immune system cells, each influence osteoclast formation and function, but the reciprocal impact of osteoclasts on these cells is less well appreciated. We highlight here the functions that osteoclasts perform beyond bone resorption. First, we consider how osteoclast signals may contribute to bone formation by osteoblasts and to the pathology of bone lesions such as fibrous dysplasia and giant cell tumors. Second, we review the interaction of osteoclasts with the hematopoietic system, including the stem cell niche and adaptive immune cells. Connections between osteoclasts and other cells in the bone microenvironment are discussed within a clinically relevant framework. As the only cells definitively shown to degrade bone, osteoclasts are key mediators of skeletal diseases including osteoporosis. Bone-forming osteoblasts, and hematopoietic and immune system cells, each influence osteoclast formation and function, but the reciprocal impact of osteoclasts on these cells is less well appreciated. We highlight here the functions that osteoclasts perform beyond bone resorption. First, we consider how osteoclast signals may contribute to bone formation by osteoblasts and to the pathology of bone lesions such as fibrous dysplasia and giant cell tumors. Second, we review the interaction of osteoclasts with the hematopoietic system, including the stem cell niche and adaptive immune cells. Connections between osteoclasts and other cells in the bone microenvironment are discussed within a clinically relevant framework.As the only cells definitively shown to degrade bone, osteoclasts are key mediators of skeletal diseases including osteoporosis. Bone-forming osteoblasts, and hematopoietic and immune system cells, each influence osteoclast formation and function, but the reciprocal impact of osteoclasts on these cells is less well appreciated. We highlight here the functions that osteoclasts perform beyond bone resorption. First, we consider how osteoclast signals may contribute to bone formation by osteoblasts and to the pathology of bone lesions such as fibrous dysplasia and giant cell tumors. Second, we review the interaction of osteoclasts with the hematopoietic system, including the stem cell niche and adaptive immune cells. Connections between osteoclasts and other cells in the bone microenvironment are discussed within a clinically relevant framework. |
| Author | Aliprantis, Antonios O. Charles, Julia F. |
| Author_xml | – sequence: 1 givenname: Julia F. surname: Charles fullname: Charles, Julia F. – sequence: 2 givenname: Antonios O. surname: Aliprantis fullname: Aliprantis, Antonios O. email: aaliprantis@partners.org |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25008556$$D View this record in MEDLINE/PubMed |
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| Snippet | •Osteoclasts modify the skeletal environment beyond their ability to resorb bone.•Bone-forming osteoblasts and their precursors are regulated by... Highlights • Osteoclasts modify the skeletal environment beyond their ability to resorb bone. • Bone-forming osteoblasts and their precursors are regulated by... As the only cells definitively shown to degrade bone, osteoclasts are key mediators of skeletal diseases including osteoporosis. Bone-forming osteoblasts, and... As the only cells definitively shown to degrade bone, osteoclasts are key mediators of skeletal diseases including osteoporosis. Bone forming osteoblasts, and... |
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| SubjectTerms | Animals Bone and Bones - metabolism Bone and Bones - pathology Bone Remodeling Bone Resorption - metabolism Bone Resorption - pathology Fibrous Dysplasia of Bone - metabolism Fibrous Dysplasia of Bone - pathology Giant Cell Tumor of Bone - metabolism Giant Cell Tumor of Bone - pathology Humans osteoblast osteoclast Osteoclasts - cytology Osteoclasts - metabolism Osteoclasts - pathology Osteogenesis osteopetrosis Osteopetrosis - metabolism Osteopetrosis - pathology osteoporosis Osteoporosis - metabolism Osteoporosis - pathology Pathology PTH |
| Title | Osteoclasts: more than ‘bone eaters’ |
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