Pancreatic Protein Tyrosine Phosphatase 1B Deficiency Exacerbates Acute Pancreatitis in Mice

• Published in: The American journal of pathology Vol. 186; no. 8; pp. 2043 - 2054
• Main Authors: Bettaieb, Ahmed, Koike, Shinichiro, Chahed, Samah, Bachaalany, Santana, Griffey, Stephen, Sastre, Juan, Haj, Fawaz G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2016; American Society for Investigative Pathology
• Subjects: Animals; Disease Models, Animal; Male; Mice; Mice, Knockout; Pancreatitis, Acute Necrotizing - metabolism; Pancreatitis, Acute Necrotizing - pathology; Pathology; Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism; Rats; Rats, Wistar; Regular; Reverse Transcriptase Polymerase Chain Reaction

Acute pancreatitis (AP) is a common and devastating gastrointestinal disorder that causes significant morbidity. The disease starts as local inflammation in the pancreas that may progress to systemic inflammation and complications. Protein tyrosine phosphatase 1B (PTP1B) is implicated in inflammator...