CREB5 promotes invasiveness and metastasis in colorectal cancer by directly activating MET

• Published in: Journal of experimental & clinical cancer research Vol. 39; no. 1; pp. 1 - 11
• Main Authors: Wang, Shuyang, Qiu, Junfeng, Liu, Lei, Su, Cailin, Qi, Lu, Huang, Chengmei, Chen, Xiaoning, Zhang, Yaxin, Ye, Yaping, Ding, Yanqing, Liang, Li, Liao, Wenting
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 25.08.2020; BioMed Central; BMC
• Subjects: Antibodies; Biopsy; Cancer metastasis; Cell cycle; Cloning; Colorectal cancer; CREB5; Development and progression; Enzymes; Gene expression; Genes; Immunohistochemistry; Invasion; Kinases; Liver cancer; Medical prognosis; MET; Metastasis; Ovarian cancer; Prostate; Protein binding; Proteins; Transcription (Genetics); Tumors; United States > US

Background cAMP responsive element binding protein 5 (CREB5) is a transcriptional activator in eukaryotic cells that can regulate gene expression. Previously, we found that CREB5 was involved in the occurrence and development of colorectal cancer (CRC) using bioinformatics analysis. However, the bio...