Abnormalities in the copper transporter CTR1 in postmortem hippocampus in schizophrenia: A subregion and laminar analysis

• Published in: Schizophrenia research Vol. 228; pp. 60 - 73
• Main Authors: Schoonover, Kirsten E., Farmer, Charlene B., Morgan, Charity J., Sinha, Vidushi, Odom, Laura, Roberts, Rosalinda C.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2021
• Subjects: Autopsy; Brain - metabolism; Copper; Copper Transporter 1 - genetics; DTNBP1 gene; Dysbindin; Dysbindin - metabolism; Entorhinal cortex; Hippocampus - metabolism; Humans; Immunohistochemistry; Psychiatric/Mental Health; Schizophrenia; Immunohistochemistry; DTNBP1 gene; Copper; Entorhinal cortex; Dysbindin

Dysbindin-1 modulates copper transport, which is crucial for cellular homeostasis. Several brain regions implicated in schizophrenia exhibit decreased levels of dysbindin-1, which may affect copper homeostasis therein. Our recent study showed decreased levels of dysbindin-1, the copper transporter-1...