aPKC-mediated displacement and actomyosin-mediated retention polarize Miranda in Drosophila neuroblasts

• Published in: eLife Vol. 7; no. 3; pp. 773 - 788
• Main Authors: Hannaford, Matthew Robert, Ramat, Anne, Loyer, Nicolas, Januschke, Jens
• Format: Journal Article
• Language: English
• Published: England eLife Science Publications, Ltd 24.01.2018; eLife Sciences Publications Ltd; eLife Sciences Publication; eLife Sciences Publications, Ltd
• Subjects: Actomyosin; Actomyosin - metabolism; Adapter proteins; Animals; asymmetric cell division; Brain; Cell cycle; Cell Cycle Proteins - metabolism; Cell division; Cell fate; Cell membranes; Cytoplasm; Developmental Biology; Drosophila; Drosophila - growth & development; Drosophila Proteins - metabolism; Experiments; Fate; Immunoglobulins; Insects; Interphase; Kinases; Larva - growth & development; Life Sciences; Localization; Mitosis; Nervous system; Neuroblasts; Neurons - physiology; Phosphorylation; polarity; Progenitor cells; Protein Binding; Protein Kinase C - metabolism; Protein Processing, Post-Translational; Regulation; Retention; Stem Cells - physiology; Canada; Venezuela; asymmetric cell division; stem cells; Drosophila; developmental biology; D. melanogaster; neuroblasts; polarity

Cell fate assignment in the nervous system of vertebrates and invertebrates often hinges on the unequal distribution of molecules during progenitor cell division. We address asymmetric fate determinant localization in the developing nervous system, specifically the control of the polarized distribut...