aPKC-mediated displacement and actomyosin-mediated retention polarize Miranda in Drosophila neuroblasts

Cell fate assignment in the nervous system of vertebrates and invertebrates often hinges on the unequal distribution of molecules during progenitor cell division. We address asymmetric fate determinant localization in the developing nervous system, specifically the control of the polarized distribut...

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Published ineLife Vol. 7; no. 3; pp. 773 - 788
Main Authors Hannaford, Matthew Robert, Ramat, Anne, Loyer, Nicolas, Januschke, Jens
Format Journal Article
LanguageEnglish
Published England eLife Science Publications, Ltd 24.01.2018
eLife Sciences Publications Ltd
eLife Sciences Publication
eLife Sciences Publications, Ltd
Subjects
Actomyosin
Actomyosin - metabolism
Adapter proteins
Animals
asymmetric cell division
Brain
Cell cycle
Cell Cycle Proteins - metabolism
Cell division
Cell fate
Cell membranes
Cytoplasm
Developmental Biology
Drosophila
Drosophila - growth & development
Drosophila Proteins - metabolism
Experiments
Fate
Immunoglobulins
Insects
Interphase
Kinases
Larva - growth & development
Life Sciences
Localization
Mitosis
Nervous system
Neuroblasts
Neurons - physiology
Phosphorylation
polarity
Progenitor cells
Protein Binding
Protein Kinase C - metabolism
Protein Processing, Post-Translational
Regulation
Retention
Stem Cells - physiology
Canada
Venezuela
asymmetric cell division
stem cells
Drosophila
developmental biology
D. melanogaster
neuroblasts
polarity
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Abstract Cell fate assignment in the nervous system of vertebrates and invertebrates often hinges on the unequal distribution of molecules during progenitor cell division. We address asymmetric fate determinant localization in the developing nervous system, specifically the control of the polarized distribution of the cell fate adapter protein Miranda. We reveal a step-wise polarization of Miranda in larval neuroblasts and find that Miranda's dynamics and cortical association are differently regulated between interphase and mitosis. In interphase, Miranda binds to the plasma membrane. Then, before nuclear envelope breakdown, Miranda is phosphorylated by aPKC and displaced into the cytoplasm. This clearance is necessary for the subsequent establishment of asymmetric Miranda localization. After nuclear envelope breakdown, actomyosin activity is required to maintain Miranda asymmetry. Therefore, phosphorylation by aPKC and differential binding to the actomyosin network are required at distinct phases of the cell cycle to polarize fate determinant localization in neuroblasts.
AbstractList Cell fate assignment in the nervous system of vertebrates and invertebrates often hinges on the unequal distribution of molecules during progenitor cell division. We address asymmetric fate determinant localization in the developing Drosophila nervous system, specifically the control of the polarized distribution of the cell fate adapter protein Miranda. We reveal a step-wise polarization of Miranda in larval neuroblasts and find that Miranda’s dynamics and cortical association are differently regulated between interphase and mitosis. In interphase, Miranda binds to the plasma membrane. Then, before nuclear envelope breakdown, Miranda is phosphorylated by aPKC and displaced into the cytoplasm. This clearance is necessary for the subsequent establishment of asymmetric Miranda localization. After nuclear envelope breakdown, actomyosin activity is required to maintain Miranda asymmetry. Therefore, phosphorylation by aPKC and differential binding to the actomyosin network are required at distinct phases of the cell cycle to polarize fate determinant localization in neuroblasts.
Cell fate assignment in the nervous system of vertebrates and invertebrates often hinges on the unequal distribution of molecules during progenitor cell division. We address asymmetric fate determinant localization in the developing nervous system, specifically the control of the polarized distribution of the cell fate adapter protein Miranda. We reveal a step-wise polarization of Miranda in larval neuroblasts and find that Miranda's dynamics and cortical association are differently regulated between interphase and mitosis. In interphase, Miranda binds to the plasma membrane. Then, before nuclear envelope breakdown, Miranda is phosphorylated by aPKC and displaced into the cytoplasm. This clearance is necessary for the subsequent establishment of asymmetric Miranda localization. After nuclear envelope breakdown, actomyosin activity is required to maintain Miranda asymmetry. Therefore, phosphorylation by aPKC and differential binding to the actomyosin network are required at distinct phases of the cell cycle to polarize fate determinant localization in neuroblasts.
Cell fate assignment in the nervous system of vertebrates and invertebrates often hinges on the unequal distribution of molecules during progenitor cell division. We address asymmetric fate determinant localization in the developing Drosophila nervous system, specifically the control of the polarized distribution of the cell fate adapter protein Miranda. We reveal a step-wise polarization of Miranda in larval neuroblasts and find that Miranda’s dynamics and cortical association are differently regulated between interphase and mitosis. In interphase, Miranda binds to the plasma membrane. Then, before nuclear envelope breakdown, Miranda is phosphorylated by aPKC and displaced into the cytoplasm. This clearance is necessary for the subsequent establishment of asymmetric Miranda localization. After nuclear envelope breakdown, actomyosin activity is required to maintain Miranda asymmetry. Therefore, phosphorylation by aPKC and differential binding to the actomyosin network are required at distinct phases of the cell cycle to polarize fate determinant localization in neuroblasts.
Audience Academic
Author Loyer, Nicolas
Januschke, Jens
Hannaford, Matthew Robert
Ramat, Anne
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  surname: Januschke
  fullname: Januschke, Jens
  organization: Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, United Kingdom
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Issue 3
Keywords asymmetric cell division
stem cells
Drosophila
developmental biology
D. melanogaster
neuroblasts
polarity
Language English
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SSID ssj0000748819
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Snippet Cell fate assignment in the nervous system of vertebrates and invertebrates often hinges on the unequal distribution of molecules during progenitor cell...
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SourceType Open Website
Open Access Repository
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StartPage 773
SubjectTerms Actomyosin
Actomyosin - metabolism
Adapter proteins
Animals
asymmetric cell division
Brain
Cell cycle
Cell Cycle Proteins - metabolism
Cell division
Cell fate
Cell membranes
Cytoplasm
Developmental Biology
Drosophila
Drosophila - growth & development
Drosophila Proteins - metabolism
Experiments
Fate
Immunoglobulins
Insects
Interphase
Kinases
Larva - growth & development
Life Sciences
Localization
Mitosis
Nervous system
Neuroblasts
Neurons - physiology
Phosphorylation
polarity
Progenitor cells
Protein Binding
Protein Kinase C - metabolism
Protein Processing, Post-Translational
Regulation
Retention
Stem Cells - physiology
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Title aPKC-mediated displacement and actomyosin-mediated retention polarize Miranda in Drosophila neuroblasts
URI https://www.ncbi.nlm.nih.gov/pubmed/29364113
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https://search.proquest.com/docview/1990854905
https://hal.science/hal-04736810
https://pubmed.ncbi.nlm.nih.gov/PMC5783611
https://doaj.org/article/3077cca4c70e454ca319eb93ab9afd61
Volume 7
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