Modifications at K31 on the lateral surface of histone H4 contribute to genome structure and expression in apicomplexan parasites

• Published in: eLife Vol. 6
• Main Authors: Sindikubwabo, Fabien, Ding, Shuai, Hussain, Tahir, Ortet, Philippe, Barakat, Mohamed, Baumgarten, Sebastian, Cannella, Dominique, Palencia, Andrés, Bougdour, Alexandre, Belmudes, Lucid, Couté, Yohann, Tardieux, Isabelle, Botté, Cyrille Y, Scherf, Artur, Hakimi, Mohamed-ali
• Format: Journal Article
• Language: English
• Published: England eLife Science Publications, Ltd 04.11.2017; eLife Sciences Publications Ltd; eLife Sciences Publication; eLife Sciences Publications, Ltd
• Subjects: Acetylation; Animals; Apicomplexa; Biochemistry; Cellular Biology; Chromatin; Chromosomes; Deoxyribonucleic acid; DNA; DNA methylation; Enzymes; Epigenesis, Genetic; Euchromatin; Gene expression; Genes; Genetic aspects; Genetics; Genomes; Genomics; Heterochromatin; Heterochromatin - metabolism; histone core modifications; Histone H4; Histones - metabolism; Life Sciences; Malaria; methylation; Microbiology and Infectious Disease; Microbiology and Parasitology; Parasites; Parasitology; Pathogenic microorganisms; Plasmodium falciparum; Plasmodium falciparum - genetics; Plasmodium falciparum - physiology; Protein Processing, Post-Translational; Proteins; RNA polymerase; Scientific equipment industry; Structure (Literature); Subcellular Processes; Toxoplasma - genetics; Toxoplasma - physiology; Toxoplasma gondii; Transcription; Transcription (Genetics); Canada; United States; acetylation; Toxoplasma gondii; infectious disease; methylation; histone core modifications; microbiology; chromatin; gene expression

An unusual genome architecture characterizes the two related human parasitic pathogens Plasmodium falciparum and Toxoplasma gondii. A major fraction of the bulk parasite genome is packaged as transcriptionally permissive euchromatin with few loci embedded in silenced heterochromatin. Primary chromat...