Factors Associated With In Vitro Interferon-gamma Production in Tuberculosis

• Published in: Journal of the Formosan Medical Association Vol. 110; no. 4; pp. 239 - 246
• Main Authors: Yu, Chung-Chieh, Liu, Yu-Chih, Chu, Chien-Ming, Chuang, Duen-Yau, Wu, Wen-Chen, Wu, Huang-Pin
• Format: Journal Article
• Language: English
• Published: Singapore Elsevier B.V 01.04.2011; Elsevier
• Subjects: Adult; Aged; Female; Humans; interferon-gamma; Interferon-gamma - biosynthesis; interleukin-10; Interleukin-10 - biosynthesis; interleukin-12; Interleukin-12 - biosynthesis; interleukin-18; Interleukin-18 - biosynthesis; Internal Medicine; Linear Models; Male; Middle Aged; Mycobacterium tuberculosis; tuberculosis; Tuberculosis - immunology; interleukin-18; interferon-gamma; interleukin-10; tuberculosis; interleukin-12

Macrophage activation assisted by interferon-gamma (IFN-γ) is a primary mechanism by which Mycobacterium tuberculosis is killed, but IFN-γ (production is inhibited in tuberculosis (TB) patients. The production of IFN-γ is influenced by many factors, such as interleukin (IL)-10, IL-12, IL-18, and cli...