Altered neuregulin 1–erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia

• Published in: Nature medicine Vol. 12; no. 7; pp. 824 - 828
• Main Authors: Hahn, Chang-Gyu, Wang, Hoau-Yan, Cho, Dan-Sung, Talbot, Konrad, Gur, Raquel E, Berrettini, Wade H, Bakshi, Kalindi, Kamins, Joshua, Borgmann-Winter, Karin E, Siegel, Steven J, Gallop, Robert J, Arnold, Steven E
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.07.2006; Nature Publishing Group
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Brain; Brain - pathology; Brain - physiopathology; Cadaver; Cancer Research; Disease Models, Animal; ErbB protein; ErbB Receptors - physiology; ErbB-2 protein; Genetic research; Genetics; Glutamate receptors; Glutamic acid receptors (ionotropic); Humans; Infectious Diseases; letter; Medical research; Mental disorders; Metabolic Diseases; Mice; Mice, Inbred C3H; Molecular Medicine; N-Methyl-D-aspartic acid receptors; Neuregulin 1; Neuregulin-1 - physiology; Neurosciences; Postsynaptic density; Postsynaptic density proteins; Prefrontal cortex; Prefrontal Cortex - pathology; Prefrontal Cortex - physiopathology; Receptor mechanisms; Receptor, ErbB-4; Receptors; Receptors, N-Methyl-D-Aspartate - physiology; Rodents; Schizophrenia; Schizophrenia - pathology; Schizophrenia - physiopathology; Signal Transduction; Stimulation; Studies

Recent molecular genetics studies implicate neuregulin 1 (NRG1) and its receptor erbB in the pathophysiology of schizophrenia 1 , 2 , 3 . Among NRG1 receptors, erbB4 is of particular interest because of its crucial roles in neurodevelopment and in the modulation of N -methyl- D -aspartate (NMDA) rec...