Altered neuregulin 1–erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia
Recent molecular genetics studies implicate neuregulin 1 (NRG1) and its receptor erbB in the pathophysiology of schizophrenia 1 , 2 , 3 . Among NRG1 receptors, erbB4 is of particular interest because of its crucial roles in neurodevelopment and in the modulation of N -methyl- D -aspartate (NMDA) rec...
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| Published in | Nature medicine Vol. 12; no. 7; pp. 824 - 828 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.07.2006
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Recent molecular genetics studies implicate neuregulin 1 (NRG1) and its receptor erbB in the pathophysiology of schizophrenia
1
,
2
,
3
. Among NRG1 receptors, erbB4 is of particular interest because of its crucial roles in neurodevelopment and in the modulation of
N
-methyl-
D
-aspartate (NMDA) receptor signaling
4
,
5
,
6
. Here, using a new postmortem tissue–stimulation approach, we show a marked increase in NRG1-induced activation of erbB4 in the prefrontal cortex in schizophrenia. Levels of NRG1 and erbB4, however, did not differ between schizophrenia and control groups. To evaluate possible causes for this hyperactivation of erbB4 signaling, we examined the association of erbB4 with PSD-95 (postsynaptic density protein of 95 kDa), as this association has been shown to facilitate activation of erbB4. Schizophrenia subjects showed substantial increases in erbB4–PSD-95 interactions. We found that NRG1 stimulation suppresses NMDA receptor activation in the human prefrontal cortex, as previously reported in the rodent cortex. NRG1-induced suppression of NMDA receptor activation was more pronounced in schizophrenia subjects than in controls, consistent with enhanced NRG1-erbB4 signaling seen in this illness. Therefore, these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia. |
|---|---|
| AbstractList | Recent molecular genetics studies implicate neuregulin 1 (NRG1) and its receptor erbB in the pathophysiology of schizophrenia. Among NRG1 receptors, erbB4 is of particular interest because of its crucial roles in neurodevelopment and in the modulation of N-methyl-D-aspartate (NMDA) receptor signaling. Here, using a new postmortem tissue-stimulation approach, we show a marked increase in NRG1-induced activation of erbB4 in the prefrontal cortex in schizophrenia. Levels of NRG1 and erbB4, however, did not differ between schizophrenia and control groups. To evaluate possible causes for this hyperactivation of erbB4 signaling, we examined the association of erbB4 with PSD-95 (postsynaptic density protein of 95 kDa), as this association has been shown to facilitate activation of erbB4. Schizophrenia subjects showed substantial increases in erbB4-PSD-95 interactions. We found that NRG1 stimulation suppresses NMDA receptor activation in the human prefrontal cortex, as previously reported in the rodent cortex. NRG1-induced suppression of NMDA receptor activation was more pronounced in schizophrenia subjects than in controls, consistent with enhanced NRG1-erbB4 signaling seen in this illness. Therefore, these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia. Recent molecular genetics studies implicate neuregulin 1 (NRG1) and its receptor erbB in the pathophysiology of schizophrenia. Among NRG1 receptors, erbB4 is of particular interest because of its crucial roles in neurodevelopment and in the modulation of N-methyl-D-aspartate (NMDA) receptor signaling. Here, using a new postmortem tissue-stimulation approach, we show a marked increase in NRG1-induced activation of erbB4 in the prefrontal cortex in schizophrenia. Levels of NRG1 and erbB4, however, did not differ between schizophrenia and control groups. To evaluate possible causes for this hyperactivation of erbB4 signaling, we examined the association of erbB4 with PSD-95 (postsynaptic density protein of 95 kDa), as this association has been shown to facilitate activation of erbB4. Schizophrenia subjects showed substantial increases in erbB4-PSD-95 interactions. We found that NRG1 stimulation suppresses NMDA receptor activation in the human prefrontal cortex, as previously reported in the rodent cortex. NRG1-induced suppression of NMDA receptor activation was more pronounced in schizophrenia subjects than in controls, consistent with enhanced NRG1-erbB4 signaling seen in this illness. Therefore, these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia.Recent molecular genetics studies implicate neuregulin 1 (NRG1) and its receptor erbB in the pathophysiology of schizophrenia. Among NRG1 receptors, erbB4 is of particular interest because of its crucial roles in neurodevelopment and in the modulation of N-methyl-D-aspartate (NMDA) receptor signaling. Here, using a new postmortem tissue-stimulation approach, we show a marked increase in NRG1-induced activation of erbB4 in the prefrontal cortex in schizophrenia. Levels of NRG1 and erbB4, however, did not differ between schizophrenia and control groups. To evaluate possible causes for this hyperactivation of erbB4 signaling, we examined the association of erbB4 with PSD-95 (postsynaptic density protein of 95 kDa), as this association has been shown to facilitate activation of erbB4. Schizophrenia subjects showed substantial increases in erbB4-PSD-95 interactions. We found that NRG1 stimulation suppresses NMDA receptor activation in the human prefrontal cortex, as previously reported in the rodent cortex. NRG1-induced suppression of NMDA receptor activation was more pronounced in schizophrenia subjects than in controls, consistent with enhanced NRG1-erbB4 signaling seen in this illness. Therefore, these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia. Recent molecular genetics studies implicate neuregulin 1 (NRG1) and its receptor erbB in the pathophysiology of schizophrenia 1 , 2 , 3 . Among NRG1 receptors, erbB4 is of particular interest because of its crucial roles in neurodevelopment and in the modulation of N -methyl- D -aspartate (NMDA) receptor signaling 4 , 5 , 6 . Here, using a new postmortem tissue–stimulation approach, we show a marked increase in NRG1-induced activation of erbB4 in the prefrontal cortex in schizophrenia. Levels of NRG1 and erbB4, however, did not differ between schizophrenia and control groups. To evaluate possible causes for this hyperactivation of erbB4 signaling, we examined the association of erbB4 with PSD-95 (postsynaptic density protein of 95 kDa), as this association has been shown to facilitate activation of erbB4. Schizophrenia subjects showed substantial increases in erbB4–PSD-95 interactions. We found that NRG1 stimulation suppresses NMDA receptor activation in the human prefrontal cortex, as previously reported in the rodent cortex. NRG1-induced suppression of NMDA receptor activation was more pronounced in schizophrenia subjects than in controls, consistent with enhanced NRG1-erbB4 signaling seen in this illness. Therefore, these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia. Recent molecular genetics studies implicate neuregulin 1 (NRG1) and its receptor erbB in the pathophysiology of schizophrenia1,2,3. Among NRG1 receptors, erbB4 is of particular interest because of its crucial roles in neurodevelopment and in the modulation of N-methyl-D-aspartate (NMDA) receptor signaling4,5,6. Here, using a new postmortem tissue–stimulation approach, we show a marked increase in NRG1-induced activation of erbB4 in the prefrontal cortex in schizophrenia. Levels of NRG1 and erbB4, however, did not differ between schizophrenia and control groups. To evaluate possible causes for this hyperactivation of erbB4 signaling, we examined the association of erbB4 with PSD-95 (postsynaptic density protein of 95 kDa), as this association has been shown to facilitate activation of erbB4. Schizophrenia subjects showed substantial increases in erbB4–PSD-95 interactions. We found that NRG1 stimulation suppresses NMDA receptor activation in the human prefrontal cortex, as previously reported in the rodent cortex. NRG1-induced suppression of NMDA receptor activation was more pronounced in schizophrenia subjects than in controls, consistent with enhanced NRG1-erbB4 signaling seen in this illness. Therefore, these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia. |
| Audience | Academic |
| Author | Kamins, Joshua Arnold, Steven E Borgmann-Winter, Karin E Berrettini, Wade H Siegel, Steven J Hahn, Chang-Gyu Cho, Dan-Sung Wang, Hoau-Yan Gur, Raquel E Talbot, Konrad Bakshi, Kalindi Gallop, Robert J |
| Author_xml | – sequence: 1 givenname: Chang-Gyu surname: Hahn fullname: Hahn, Chang-Gyu email: hahnc@mail.med.upenn.edu organization: Department of Psychiatry, Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, University of Pennsylvania – sequence: 2 givenname: Hoau-Yan surname: Wang fullname: Wang, Hoau-Yan organization: Department of Physiology and Pharmacology, City University of New York Medical School – sequence: 3 givenname: Dan-Sung surname: Cho fullname: Cho, Dan-Sung organization: Department of Psychiatry, Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, University of Pennsylvania – sequence: 4 givenname: Konrad surname: Talbot fullname: Talbot, Konrad organization: Department of Psychiatry, Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, University of Pennsylvania – sequence: 5 givenname: Raquel E surname: Gur fullname: Gur, Raquel E organization: Department of Psychiatry, Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, University of Pennsylvania – sequence: 6 givenname: Wade H surname: Berrettini fullname: Berrettini, Wade H organization: Department of Psychiatry, Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, University of Pennsylvania – sequence: 7 givenname: Kalindi surname: Bakshi fullname: Bakshi, Kalindi organization: Department of Physiology and Pharmacology, City University of New York Medical School – sequence: 8 givenname: Joshua surname: Kamins fullname: Kamins, Joshua organization: Department of Psychiatry, Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, University of Pennsylvania – sequence: 9 givenname: Karin E surname: Borgmann-Winter fullname: Borgmann-Winter, Karin E organization: Department of Psychiatry, Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, University of Pennsylvania – sequence: 10 givenname: Steven J surname: Siegel fullname: Siegel, Steven J organization: Department of Psychiatry, Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, University of Pennsylvania – sequence: 11 givenname: Robert J surname: Gallop fullname: Gallop, Robert J organization: Department of Mathematics, Applied Statistics Program, West Chester University, 323 Anderson Hall – sequence: 12 givenname: Steven E surname: Arnold fullname: Arnold, Steven E organization: Department of Psychiatry, Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, University of Pennsylvania |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16767099$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/S0079-6123(04)47023-X 10.1523/JNEUROSCI.2100-05.2005 10.1038/37795 10.1016/S0896-6273(00)81176-9 10.1016/S0896-6273(00)80346-3 10.1046/j.1471-4159.2002.01181.x 10.1146/annurev.neuro.20.1.429 10.1196/annals.1300.020 10.1016/S0140-6736(03)12379-3 10.1016/0304-3940(94)90144-9 10.1038/sj.npp.1300451 10.1046/j.1471-4159.2001.t01-1-00132.x 10.1016/S0896-6273(03)00757-8 10.1523/JNEUROSCI.1086-05.2005 10.1523/JNEUROSCI.19-24-10757.1999 10.1038/sj.mp.4001348 10.1080/07853890310017585 10.1016/S0959-4388(00)00210-5 10.1038/nn1345 10.1146/annurev.neuro.24.1.87 10.1086/342734 10.1002/hipo.10185 10.1038/sj.mp.4001412 10.1038/sj.mp.4001558 10.1038/sj.mp.4001434 10.1073/pnas.97.7.3596 10.1016/0006-3223(95)00611-7 |
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| References | JT Coyle (BFnm1418_CR24) 2003; 1003 GD Fischbach (BFnm1418_CR8) 1997; 20 Z Gu (BFnm1418_CR16) 2005; 25 AP Corvin (BFnm1418_CR3) 2004; 9 A Buonanno (BFnm1418_CR9) 2001; 11 HY Wang (BFnm1418_CR20) 1996; 40 RA Garcia (BFnm1418_CR21) 2000; 97 H Stefansson (BFnm1418_CR7) 2004; 36 HY Wang (BFnm1418_CR19) 1994; 173 G Lemke (BFnm1418_CR10) 2001; 24 R Hashimoto (BFnm1418_CR17) 2004; 9 M Okada (BFnm1418_CR14) 2004; 14 PJ Harrison (BFnm1418_CR27) 2003; 361 SM Clinton (BFnm1418_CR22) 2004; 29 H Stefansson (BFnm1418_CR1) 2002; 71 SE Arnold (BFnm1418_CR11) 2005; 147 KE Frenzel (BFnm1418_CR18) 2001; 77 M Ozaki (BFnm1418_CR6) 1997; 390 C Rio (BFnm1418_CR13) 1997; 19 NM Williams (BFnm1418_CR2) 2003; 8 OB Kwon (BFnm1418_CR26) 2005; 25 ES Anton (BFnm1418_CR4) 2004; 7 HI Rieff (BFnm1418_CR5) 1999; 19 K Toyooka (BFnm1418_CR23) 2002; 83 PJ Harrison (BFnm1418_CR12) 2005; 10 YZ Huang (BFnm1418_CR15) 2000; 26 B Moghaddam (BFnm1418_CR25) 2003; 40 16829916 - Nat Med. 2006 Jul;12(7):734-5 38114668 - Nat Med. 2023 Dec 19 |
| References_xml | – volume: 147 start-page: 319 year: 2005 ident: BFnm1418_CR11 publication-title: Prog. Brain Res. doi: 10.1016/S0079-6123(04)47023-X – volume: 25 start-page: 9378 year: 2005 ident: BFnm1418_CR26 publication-title: J. Neurosci doi: 10.1523/JNEUROSCI.2100-05.2005 – volume: 390 start-page: 691 year: 1997 ident: BFnm1418_CR6 publication-title: Nature doi: 10.1038/37795 – volume: 26 start-page: 443 year: 2000 ident: BFnm1418_CR15 publication-title: Neuron doi: 10.1016/S0896-6273(00)81176-9 – volume: 19 start-page: 39 year: 1997 ident: BFnm1418_CR13 publication-title: Neuron doi: 10.1016/S0896-6273(00)80346-3 – volume: 83 start-page: 797 year: 2002 ident: BFnm1418_CR23 publication-title: J. Neurochem. doi: 10.1046/j.1471-4159.2002.01181.x – volume: 20 start-page: 429 year: 1997 ident: BFnm1418_CR8 publication-title: Annu. Rev. Neurosci. doi: 10.1146/annurev.neuro.20.1.429 – volume: 1003 start-page: 318 year: 2003 ident: BFnm1418_CR24 publication-title: Ann. NY Acad. Sci. doi: 10.1196/annals.1300.020 – volume: 361 start-page: 417 year: 2003 ident: BFnm1418_CR27 publication-title: Lancet doi: 10.1016/S0140-6736(03)12379-3 – volume: 173 start-page: 37 year: 1994 ident: BFnm1418_CR19 publication-title: Neurosci. Lett. doi: 10.1016/0304-3940(94)90144-9 – volume: 29 start-page: 1353 year: 2004 ident: BFnm1418_CR22 publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1300451 – volume: 77 start-page: 1 year: 2001 ident: BFnm1418_CR18 publication-title: J. Neurochem. doi: 10.1046/j.1471-4159.2001.t01-1-00132.x – volume: 40 start-page: 881 year: 2003 ident: BFnm1418_CR25 publication-title: Neuron doi: 10.1016/S0896-6273(03)00757-8 – volume: 25 start-page: 4974 year: 2005 ident: BFnm1418_CR16 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1086-05.2005 – volume: 19 start-page: 10757 year: 1999 ident: BFnm1418_CR5 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.19-24-10757.1999 – volume: 8 start-page: 485 year: 2003 ident: BFnm1418_CR2 publication-title: Mol. Psychiatry doi: 10.1038/sj.mp.4001348 – volume: 36 start-page: 62 year: 2004 ident: BFnm1418_CR7 publication-title: Ann. Med. doi: 10.1080/07853890310017585 – volume: 11 start-page: 287 year: 2001 ident: BFnm1418_CR9 publication-title: Curr. Opin. Neurobiol. doi: 10.1016/S0959-4388(00)00210-5 – volume: 7 start-page: 1319 year: 2004 ident: BFnm1418_CR4 publication-title: Nat. Neurosci. doi: 10.1038/nn1345 – volume: 24 start-page: 87 year: 2001 ident: BFnm1418_CR10 publication-title: Annu. Rev. Neurosci. doi: 10.1146/annurev.neuro.24.1.87 – volume: 71 start-page: 877 year: 2002 ident: BFnm1418_CR1 publication-title: Am. J. Hum. Genet. doi: 10.1086/342734 – volume: 14 start-page: 337 year: 2004 ident: BFnm1418_CR14 publication-title: Hippocampus doi: 10.1002/hipo.10185 – volume: 9 start-page: 208 year: 2004 ident: BFnm1418_CR3 publication-title: Mol. Psychiatry doi: 10.1038/sj.mp.4001412 – volume: 10 start-page: 40 year: 2005 ident: BFnm1418_CR12 publication-title: Mol. Psychiatry doi: 10.1038/sj.mp.4001558 – volume: 9 start-page: 299 year: 2004 ident: BFnm1418_CR17 publication-title: Mol. Psychiatry doi: 10.1038/sj.mp.4001434 – volume: 97 start-page: 3596 year: 2000 ident: BFnm1418_CR21 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.97.7.3596 – volume: 40 start-page: 568 year: 1996 ident: BFnm1418_CR20 publication-title: Biol. Psychiatry doi: 10.1016/0006-3223(95)00611-7 – reference: 38114668 - Nat Med. 2023 Dec 19;: – reference: 16829916 - Nat Med. 2006 Jul;12(7):734-5 |
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| Snippet | Recent molecular genetics studies implicate neuregulin 1 (NRG1) and its receptor erbB in the pathophysiology of schizophrenia
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. Among NRG1 receptors,... Recent molecular genetics studies implicate neuregulin 1 (NRG1) and its receptor erbB in the pathophysiology of schizophrenia. Among NRG1 receptors, erbB4 is... Recent molecular genetics studies implicate neuregulin 1 (NRG1) and its receptor erbB in the pathophysiology of schizophrenia1,2,3. Among NRG1 receptors, erbB4... |
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| SubjectTerms | Animals Biomedical and Life Sciences Biomedicine Brain Brain - pathology Brain - physiopathology Cadaver Cancer Research Disease Models, Animal ErbB protein ErbB Receptors - physiology ErbB-2 protein Genetic research Genetics Glutamate receptors Glutamic acid receptors (ionotropic) Humans Infectious Diseases letter Medical research Mental disorders Metabolic Diseases Mice Mice, Inbred C3H Molecular Medicine N-Methyl-D-aspartic acid receptors Neuregulin 1 Neuregulin-1 - physiology Neurosciences Postsynaptic density Postsynaptic density proteins Prefrontal cortex Prefrontal Cortex - pathology Prefrontal Cortex - physiopathology Receptor mechanisms Receptor, ErbB-4 Receptors Receptors, N-Methyl-D-Aspartate - physiology Rodents Schizophrenia Schizophrenia - pathology Schizophrenia - physiopathology Signal Transduction Stimulation Studies |
| Title | Altered neuregulin 1–erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia |
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