Highly efficient induction and long-term maintenance of multipotent cardiovascular progenitors from human pluripotent stem cells under defined conditions

• Published in: Cell research Vol. 23; no. 9; pp. 1119 - 1132
• Main Authors: Cao, Nan, Liang, He, Huang, Jijun, Wang, Jia, Chen, Yixiong, Chen, Zhongyan, Yang, Huang-Tian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2013; Nature Publishing Group
• Subjects: 631/136/532/1360; 631/136/532/2064; 631/1647/1407/651; 692/699/75; Ascorbic Acid - pharmacology; Biomedical and Life Sciences; Bone Morphogenetic Protein 4 - pharmacology; Cardiovascular diseases; Cell Biology; Cell Culture Techniques; Cell Differentiation - drug effects; Cell- and Tissue-Based Therapy; Cells, Cultured; Embryonic Stem Cells - drug effects; Embryonic Stem Cells - metabolism; Glycogen Synthase Kinase 3 - antagonists & inhibitors; Heart - embryology; Heart Diseases - therapy; Humans; Induced Pluripotent Stem Cells - drug effects; Induced Pluripotent Stem Cells - metabolism; Life Sciences; Myocardium - cytology; Original; original-article; Pyridines - pharmacology; Pyrimidines - pharmacology; Stem cells; 人类胚胎干细胞; 分化诱导; 多能干细胞; 心血管; 祖细胞; 自我更新; 血管发育; 骨形态发生蛋白; directed differentiation; human pluripotent stem cells; cardiovascular progenitor cells; chemically defined medium; progenitor maintenance

Cardiovascular progenitor cells （CVPCs） derived from human pluripotent stem cells （hPSCs）, including human embryonic stem cells （hESCs） and human induced pluripotent stem cells （hiPSCs）, hold great promise for the study of cardiovascular development and cell-based therapy of heart diseases, but thei...