Understanding and targeting cancer stem cells： therapeutic implications and challenges

• Published in: Acta pharmacologica Sinica Vol. 34; no. 6; pp. 732 - 740
• Main Authors: Chen, Ke, Huang, Ying-hui, Chen, Ji-long
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2013; Nature Publishing Group
• Subjects: Animals; Antineoplastic Agents - pharmacology; Biomedical and Life Sciences; Biomedicine; Cell Differentiation - physiology; CSC; Disease Progression; Drug Design; Drug Resistance, Neoplasm; Humans; Immunology; Internal Medicine; Medical Microbiology; Molecular Targeted Therapy; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasms - drug therapy; Neoplasms - pathology; Neoplastic Stem Cells - drug effects; Neoplastic Stem Cells - metabolism; Pharmacology/Toxicology; Review; Vaccine; 信号通路; 分子识别; 干细胞治疗; 细胞群体; 肿瘤干细胞; 肿瘤细胞; 自我更新; leukemia; stem cell; signaling pathway; cancer; tumor microenvironment; biomarker; ATP-binding cassette transporter

Cancer stem cells （CSCs） have been identified as rare cell populations in many cancers, including leukemia and solid tumors. Accumulating evidence has suggested that CSCs are capable of self-renewal and differentiation into various types of cancer cells. Aberrant regulation of gene expression and so...