Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis

• Published in: Nature immunology Vol. 20; no. 1; pp. 86 - 96
• Main Authors: Hatzi, Katerina, Geng, Huimin, Doane, Ashley S., Meydan, Cem, LaRiviere, Reed, Cardenas, Mariano, Duy, Cihangir, Shen, Hao, Vidal, Maria Nieves Calvo, Baslan, Timour, Mohammad, Helai P., Kruger, Ryan G., Shaknovich, Rita, Haberman, Ann M., Inghirami, Giorgio, Lowe, Scott W., Melnick, Ari M.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.01.2019; Nature Publishing Group
• Subjects: 631/250/1619/40; 631/250/2152/2153/1982; 631/250/2502/2170; 631/67/1990/291; Animals; B cells; B-Lymphocytes - physiology; Bcl-6 protein; Biomedical and Life Sciences; Biomedicine; Carcinogenesis; Clonal deletion; CRISPR; CRISPR-Cas Systems; Dependence; Development and progression; DNA, Intergenic - genetics; Enhancers; Gene expression; Genes; Genetic aspects; Germinal Center - immunology; Germinal Center - pathology; Germinal centers; Histone Demethylases - genetics; Histone Demethylases - metabolism; Hyperplasia; Immune response; Immune response (humoral); Immunological Synapses - genetics; Immunology; Infectious Diseases; Introns - genetics; Lymphocytes B; Lymphoma; Lymphoma - genetics; Lymphoma - metabolism; Lymphomas; Mice; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins c-bcl-6 - genetics; Proto-Oncogene Proteins c-bcl-6 - metabolism; Transcription; Transcription (Genetics); Transcription factors; Tumors

Germinal center (GC) B cells feature repression of many gene enhancers to establish their characteristic transcriptome. Here we show that conditional deletion of Lsd1 in GCs significantly impaired GC formation, associated with failure to repress immune synapse genes linked to GC exit, which are also...