Sterically Shielded Heptamethine Cyanine Dyes for Bioconjugation and High Performance Near‐Infrared Fluorescence Imaging

• Published in: Angewandte Chemie International Edition Vol. 59; no. 29; pp. 12154 - 12161
• Main Authors: Li, Dong‐Hao, Schreiber, Cynthia L., Smith, Bradley D.
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 13.07.2020; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Animals; Antibodies; Antifungal agents; Aromatic compounds; Carbocyanines - chemical synthesis; Carbocyanines - chemistry; Cell Line, Tumor; Chemistry; Chemistry, Multidisciplinary; Cyanine dyes; cyanines; Dye penetrants; Dyes; dyes/pigments; Fluorescence; Fluorescent Dyes - chemistry; fluorescent probes; imaging agents; Infrared imaging; Infrared windows; Medical imaging; Mice; Molecular Imaging; Molecular Structure; Optical Imaging; Pharmacokinetics; Physical Sciences; Physiochemistry; Science & Technology; Shielding; Spectroscopy, Near-Infrared; Tissue Distribution; pigments; FLUOROPHORES; TRACERS; imaging agents; PHOTOPHYSICAL PROPERTIES; dyes; fluorescent probes; CONJUGATION; IMPACT; antibodies; cyanines; BINDING; PROBE; dyes/pigments

The near‐infrared window of fluorescent heptamethine cyanine dyes greatly facilitates biological imaging because there is deep penetration of the light and negligible background fluorescence. However, dye instability, aggregation, and poor pharmacokinetics are current drawbacks that limit performanc...