Patient‐derived organoids for personalized gallbladder cancer modelling and drug screening

• Published in: Clinical and translational medicine Vol. 12; no. 1; pp. e678 - n/a
• Main Authors: Yuan, Bo, Zhao, Xiaofang, Wang, Xiang, Liu, Erdong, Liu, Chunliang, Zong, Yali, Jiang, Youhai, Hou, Minghui, Chen, Yao, Chen, Lei, Zhang, Yongjie, Wang, Hongyang, Fu, Jing
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.01.2022; John Wiley and Sons Inc; Wiley
• Subjects: Adult; Aged; Aged, 80 and over; Cancer therapies; Clinical medicine; drug screening; Drug Screening Assays, Antitumor - methods; Drug Screening Assays, Antitumor - statistics & numerical data; Early Detection of Cancer - instrumentation; Early Detection of Cancer - methods; Early Detection of Cancer - statistics & numerical data; Exome Sequencing - methods; Exome Sequencing - statistics & numerical data; Female; Gallbladder; Gallbladder cancer; Gallbladder Neoplasms - diagnosis; Gallbladder Neoplasms - therapy; Gallstones; Gene expression; HDAC; Histology; Humans; Male; Middle Aged; Models, Biological; Mutation; organoids; Organoids - pathology; Patients; Precision Medicine - instrumentation; Precision Medicine - methods; Precision Medicine - statistics & numerical data; Surgery; United States > US; China; Germany; gallbladder cancer; drug screening; organoids; HDAC

Background Gallbladder carcinoma (GBC) is a relatively rare but highly aggressive cancer with late clinical detection and a poor prognosis. However, the lack of models with features consistent with human gallbladder tumours has hindered progress in pathogenic mechanisms and therapies. Methods We est...