Acid‐Activatable Transmorphic Peptide‐Based Nanomaterials for Photodynamic Therapy

• Published in: Angewandte Chemie International Edition Vol. 59; no. 46; pp. 20582 - 20588
• Main Authors: Sun, Bingbing, Chang, Rui, Cao, Shoupeng, Yuan, Chengqian, Zhao, Luyang, Yang, Haowen, Li, Junbai, Yan, Xuehai, Hest, Jan C. M.
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 09.11.2020; Wiley Subscription Services, Inc; John Wiley and Sons Inc
• Edition: International ed. in English
• Subjects: Acids - chemistry; Assemblies; Biomaterials; Biomedical materials; Chemistry; Chemistry, Multidisciplinary; fibrillar transformation; Fibrils; Fluorescence; Humans; Hydrogen bonds; Hydrogen-Ion Concentration; Morphology; Nanofibers; Nanomaterials; Nanoparticles; Nanostructures - chemistry; Nanotechnology; Peptides; Peptides - chemistry; Photochemotherapy - methods; Photodynamic therapy; photosensitizers; Photosensitizing Agents - chemistry; Physical Sciences; Porphyrins; Porphyrins - chemistry; Retention; Science & Technology; self-assembly; Singlet oxygen; Spectrum Analysis - methods; Tumor Microenvironment; Tumors; self-assembly; NANOPARTICLES; fibrillar transformation; photodynamic therapy; RETENTION; PH; peptides; photosensitizers; PI-PI-STACKING; ELECTROSTATIC REPULSION; COMBINATION; CANCER

Inspired by the dynamic morphology control of molecular assemblies in biological systems, we have developed pH‐responsive transformable peptide‐based nanoparticles for photodynamic therapy (PDT) with prolonged tumor retention times. The self‐assembled peptide–porphyrin nanoparticles transformed into...