Montgomery‐Åsberg Depression Rating Scale factors in treatment‐resistant depression at onset of treatment: Derivation, replication, and change over time during treatment with esketamine

• Published in: International journal of methods in psychiatric research Vol. 31; no. 4; pp. e1927 - n/a
• Main Authors: Borentain, Stephane, Gogate, Jagadish, Williamson, David, Carmody, Thomas, Trivedi, Madhukar, Jamieson, Carol, Cabrera, Patricia, Popova, Vanina, Wajs, Ewa, DiBernardo, Allitia, Daly, Ella J.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.12.2022; John Wiley and Sons Inc; Wiley
• Subjects: Adult; Analysis; Antidepressants; Appetite loss; Clinical trials; Depression; Depression, Mental; Depressive Disorder, Treatment-Resistant - drug therapy; Double-Blind Method; Drug dosages; Drug therapy; esketamine; Evaluation; Factor analysis; FDA approval; Humans; Ketamine; Ketamine - pharmacology; Ketamine - therapeutic use; MADRS; Mental depression; Mental disorders; Nasal Sprays; Original; Patients; Placebos; Sleep deprivation; Treatment Outcome; Treatment resistance; United States > US; factor analysis; MADRS; depression; esketamine

Objective Derive and confirm factor structure of the Montgomery‐Åsberg Depression Rating Scale (MADRS) in patients with treatment‐resistant depression (TRD) and evaluate how the factors evident at baseline change over 4 weeks of esketamine treatment. Methods Two similarly‐designed, short‐term TRANSF...