Elevated Serum C-Reactive Protein Levels and Advanced Atherosclerosis in Youth

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 25; no. 6; pp. 1237 - 1243
• Main Authors: Zieske, Arthur W., Tracy, Russell P., McMahan, C Alex, Herderick, Edward E., Homma, Satoki, Malcom, Gray T., McGill, Henry C., Strong, Jack P.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.06.2005; Hagerstown, MD Lippincott
• Subjects: Adolescent; Adult; African Continental Ancestry Group - statistics & numerical data; Age Distribution; Aorta, Abdominal - pathology; Associated diseases and complications; Atherosclerosis (general aspects, experimental research); Atherosclerosis - blood; Atherosclerosis - epidemiology; Atherosclerosis - pathology; Biological and medical sciences; Biomarkers; Blood and lymphatic vessels; C-Reactive Protein - metabolism; Cardiology. Vascular system; Cardiovascular system; Coronary Disease - blood; Coronary Disease - epidemiology; Coronary Disease - pathology; Coronary Vessels - pathology; Diabetes. Impaired glucose tolerance; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; European Continental Ancestry Group - statistics & numerical data; Female; Humans; Investigative techniques of hemodynamics; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Prevalence; Risk Factors; Smoking - epidemiology; Vascular disease; risk factors; C-reactive protein; Atherosclerosis; Risk factor; Cardiovascular disease; C reactive protein; Coronary heart disease; youth

OBJECTIVE—To determine the associations among serum C-reactive protein (CRP) concentration, age, sex, risk factors for coronary heart disease (CHD), and atherosclerosis in young people. METHODS AND RESULTS—In 1244 subjects 15 to 34 years of age, we measured gross atherosclerotic lesions in the right...