Organic CO Prodrugs: Structure–CO‐Release Rate Relationship Studies

Carbon monoxide (CO) is an endogenously produced gasotransmitter in mammals, and may have signaling roles in bacteria as well. It has many recognized therapeutic effects. A significant challenge in this field is the development of pharmaceutically acceptable forms of CO delivery with controllable an...

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Published inChemistry : a European journal Vol. 23; no. 41; pp. 9838 - 9845
Main Authors Pan, Zhixiang, Chittavong, Vayou, Li, Wei, Zhang, Jun, Ji, Kaili, Zhu, Mengyuan, Ji, Xingyue, Wang, Binghe
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 21.07.2017
Wiley Subscription Services, Inc
Subjects
Animals
Aqueous solutions
Bacteria
Carbon monoxide
Carbon Monoxide - chemistry
Carbon Monoxide - metabolism
Cell Survival - drug effects
Chemical compounds
Chemistry
Chemistry, Multidisciplinary
click and release
Drug Design
Drugs
Hydrogen-Ion Concentration
Kinetics
Mammals
metal free
Mice
Microscopy, Fluorescence
Myoglobin - chemistry
Myoglobin - metabolism
Physical Sciences
Prodrugs
Prodrugs - chemical synthesis
Prodrugs - chemistry
Prodrugs - toxicity
RAW 264.7 Cells
release rate
Science & Technology
Water - chemistry
DESIGN
DIELS-ALDER REACTIONS
PHOTOCORMS
COMPLEXES
carbon monoxide
click and release
prodrugs
metal free
MOLECULES
DELIVERY
VISIBLE-LIGHT
CARBON-MONOXIDE
release rate
CLICK
FLUORESCENT-PROBE
Online AccessGet full text
ISSN0947-6539
1521-3765
1521-3765
DOI10.1002/chem.201700936

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Abstract Carbon monoxide (CO) is an endogenously produced gasotransmitter in mammals, and may have signaling roles in bacteria as well. It has many recognized therapeutic effects. A significant challenge in this field is the development of pharmaceutically acceptable forms of CO delivery with controllable and tunable release rates. Herein, the structure–release rate studies of the first class of organic CO prodrugs that release CO in aqueous solution at neutral pH is described. Structure–CO‐release rate relationship studies of organic CO prodrugs reveal that CO releasing rate can be tuned by modifying the nature of the linker, substituents on dienone ring or linker, and the length of the linker.
AbstractList Carbon monoxide (CO) is an endogenously produced gasotransmitter in mammals, and may have signaling roles in bacteria as well. It has many recognized therapeutic effects. A significant challenge in this field is the development of pharmaceutically acceptable forms of CO delivery with controllable and tunable release rates. Herein, the structure–release rate studies of the first class of organic CO prodrugs that release CO in aqueous solution at neutral pH is described.
Carbon monoxide (CO) is an endogenously produced gasotransmitter in mammals, and may have signaling roles in bacteria as well. It has many recognized therapeutic effects. A significant challenge in this field is the development of pharmaceutically acceptable forms of CO delivery with controllable and tunable release rates. Herein, the structure-release rate studies of the first class of organic CO prodrugs that release CO in aqueous solution at neutral pH is described.Carbon monoxide (CO) is an endogenously produced gasotransmitter in mammals, and may have signaling roles in bacteria as well. It has many recognized therapeutic effects. A significant challenge in this field is the development of pharmaceutically acceptable forms of CO delivery with controllable and tunable release rates. Herein, the structure-release rate studies of the first class of organic CO prodrugs that release CO in aqueous solution at neutral pH is described.
Carbon monoxide (CO) is an endogenously produced gasotransmitter in mammals, and may have signaling roles in bacteria as well. It has many recognized therapeutic effects. A significant challenge in this field is the development of pharmaceutically acceptable forms of CO delivery with controllable and tunable release rates. Herein, the structure–release rate studies of the first class of organic CO prodrugs that release CO in aqueous solution at neutral pH is described. Structure–CO‐release rate relationship studies of organic CO prodrugs reveal that CO releasing rate can be tuned by modifying the nature of the linker, substituents on dienone ring or linker, and the length of the linker.
Carbon monoxide (CO) is an endogenously produced gasotransmitter in mammals, and may have signaling roles in bacteria as well. It has many recognized therapeutic effects. A significant challenge in this field is the development of pharmaceutically acceptable forms of CO delivery with controllable and tunable release rates. Herein, we describe the structure-release rate studies of the first class of organic CO-prodrugs that release CO in aqueous solution at neutral pH. Structure CO-release rate relationship studies of organic CO prodrugs reveals that CO releasing rate can be tuned by modifying the nature of the linker, substituents on dienone ring or linker, and the length of the linker.
Author Wang, Binghe
Pan, Zhixiang
Ji, Kaili
Zhu, Mengyuan
Li, Wei
Zhang, Jun
Chittavong, Vayou
Ji, Xingyue
Author_xml – sequence: 1
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  surname: Pan
  fullname: Pan, Zhixiang
  organization: Georgia State University
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  surname: Chittavong
  fullname: Chittavong, Vayou
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  surname: Li
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  organization: Jining Medical University
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  surname: Zhang
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  organization: Georgia State University
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  organization: Georgia State University
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  surname: Wang
  fullname: Wang, Binghe
  email: wang@gsu.edu
  organization: Georgia State University
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Issue 41
Keywords DESIGN
DIELS-ALDER REACTIONS
PHOTOCORMS
COMPLEXES
carbon monoxide
click and release
prodrugs
metal free
MOLECULES
DELIVERY
VISIBLE-LIGHT
CARBON-MONOXIDE
release rate
CLICK
FLUORESCENT-PROBE
Language English
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Snippet Carbon monoxide (CO) is an endogenously produced gasotransmitter in mammals, and may have signaling roles in bacteria as well. It has many recognized...
Source Web of Science
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StartPage 9838
SubjectTerms Animals
Aqueous solutions
Bacteria
Carbon monoxide
Carbon Monoxide - chemistry
Carbon Monoxide - metabolism
Cell Survival - drug effects
Chemical compounds
Chemistry
Chemistry, Multidisciplinary
click and release
Drug Design
Drugs
Hydrogen-Ion Concentration
Kinetics
Mammals
metal free
Mice
Microscopy, Fluorescence
Myoglobin - chemistry
Myoglobin - metabolism
Physical Sciences
Prodrugs
Prodrugs - chemical synthesis
Prodrugs - chemistry
Prodrugs - toxicity
RAW 264.7 Cells
release rate
Science & Technology
Water - chemistry
Title Organic CO Prodrugs: Structure–CO‐Release Rate Relationship Studies
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fchem.201700936
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=FullRecord&UT=000405923800020
https://www.ncbi.nlm.nih.gov/pubmed/28544290
https://www.proquest.com/docview/1920605290
https://www.proquest.com/docview/1903164944
https://pubmed.ncbi.nlm.nih.gov/PMC5679012
Volume 23
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