Inhibition of endoplasmic reticulum stress prevents high‐fat diet mediated atrial fibrosis and fibrillation

• Published in: Journal of Cellular and Molecular Medicine Vol. 24; no. 23; pp. 13660 - 13668
• Main Authors: Zhang, Yan, Yang, Shuwen, Fu, Jing, Liu, Annan, Liu, Deping, Cao, Suyan
• Format: Journal Article
• Language: English
• Published: England Wiley 01.12.2020; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: Age; Aged; Animals; Arrhythmia; Atrial Fibrillation; Atrial Fibrillation - diagnosis; Atrial Fibrillation - etiology; Atrial Fibrillation - metabolism; Atrial Fibrillation - prevention & control; atrial fibrosis; Atrium; Biomarkers; Body mass index; Body weight; Cardiac arrhythmia; Cardiovascular disease; CHOP protein; Chronic obstructive pulmonary disease; Collagen; Comorbidity; Coronary vessels; Diabetes; Diet, High-Fat; Diet, High-Fat - adverse effects; Disease Models, Animal; Disease Susceptibility; Echocardiography; Electrical stimuli; Electrocardiography; Endoplasmic reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Endoplasmic Reticulum Stress - drug effects; Female; Fibrillation; Fibrosis; Glucose; Heart Atria; Heart Atria - drug effects; Heart Atria - pathology; Heart Atria - physiopathology; High fat diet; Humans; Immunohistochemistry; Incidence; Laboratory animals; Male; Mice; Middle Aged; Morbidity; Normal distribution; Obesity; Obesity - complications; Obesity - metabolism; Original; Original Articles; Overweight; Overweight - complications; Overweight - metabolism; Phenylbutyric acid; Proteins; Risk factors; Software; Statistical analysis; Weight control; atrial fibrosis; atrial fibrillation; endoplasmic reticulum stress; high-fat diet

Obesity is a significant risk factor for atrial fibrillation (AF), which is the most common sustained arrhythmia with increased mortality and morbidity. High‐fat diet (HFD)‐induced obesity is associated with the activation of endoplasmic reticulum stress (ERS). However, the role of ERS in HFD‐induce...