Hypertrophic cardiomyopathy and dysregulation of cardiac energetics in a mouse model of biliary fibrosis

• Published in: Hepatology (Baltimore, Md.) Vol. 51; no. 6; pp. 2097 - 2107
• Main Authors: Desai, Moreshwar S., Shabier, Zainuer, Taylor, Michael, Lam, Fong, Thevananther, Sundararajah, Kosters, Astrid, Karpen, Saul J.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2010; Wiley; Wiley Subscription Services, Inc
• Subjects: Animals; Bile; Bile Acids and Salts - blood; Bile Duct Diseases - chemically induced; Bile Duct Diseases - complications; Bile Duct Diseases - metabolism; Bile Duct Diseases - physiopathology; Biological and medical sciences; Cardiology. Vascular system; Cardiomyopathy; Cardiomyopathy, Hypertrophic - etiology; Dicarbethoxydihydrocollidine; Disease Models, Animal; Fatigue - chemically induced; Fatigue - complications; Fatty Acids - metabolism; Fibrosis; Fitness equipment; Gastroenterology. Liver. Pancreas. Abdomen; Gene Expression - drug effects; Glycogen - metabolism; Heart; Heart - physiopathology; Hepatology; Kinases; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Mice; Mice, Inbred C57BL; Mortality; Myocarditis. Cardiomyopathies; Myocardium - metabolism; Myocardium - pathology; Oxygen Consumption; Phenotype; Receptors, Adrenergic, beta - metabolism; Receptors, G-Protein-Coupled - metabolism; Respiratory Function Tests; Rodents; Signal Transduction; Heart; Biliary tract; Rodentia; Cardiovascular disease; Myocardial disease; Vertebrata; Mammalia; Mouse; Heart disease; Animal; Fibrosis; Gastroenterology; Hypertrophic cardiomyopathy; Models

Cardiac dysfunction is a major cause of morbidity and mortality in patients with end‐stage liver disease; yet the mechanisms remain largely unknown. We hypothesized that the complex interrelated impairments in cardiac structure and function secondary to progression of liver diseases involve alterati...