Variant Aldehyde Dehydrogenase 2 (ALDH22) Is a Risk Factor for Coronary Spasm and ST‐Segment Elevation Myocardial Infarction

• Published in: Journal of the American Heart Association Vol. 5; no. 5
• Main Authors: Mizuno, Yuji, Hokimoto, Seiji, Harada, Eisaku, Kinoshita, Kenji, Nakagawa, Kazuko, Yoshimura, Michihiro, Ogawa, Hisao, Yasue, Hirofumi
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 06.05.2016; Wiley
• Subjects: acute myocardial infarction; Aged; alcohol flushing syndrome; aldehyde dehydrogenase 2; Aldehyde Dehydrogenase, Mitochondrial - genetics; Asian Continental Ancestry Group; Central Nervous System Depressants - adverse effects; coronary spasm; coronary spastic angina; Coronary Vasospasm - genetics; Creatine Kinase - blood; Ethanol - adverse effects; Female; Flushing - chemically induced; Flushing - genetics; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Japan; Male; Middle Aged; Original Research; Percutaneous Coronary Intervention; Risk Factors; Severity of Illness Index; ST Elevation Myocardial Infarction - blood; ST Elevation Myocardial Infarction - genetics; ST Elevation Myocardial Infarction - surgery; Troponin T - blood; alcohol flushing syndrome; aldehyde dehydrogenase 2; coronary spasm; coronary spastic angina; acute myocardial infarction

Background Mitochondrial aldehyde dehydrogenase 2 (ALDH2) plays a key role in removing toxic aldehydes. Deficient variant ALDH2*2 genotype is prevalent in up to 40% of the East Asians and reported to be associated with acute myocardial infarction (AMI). To elucidate the mechanisms underlying the ass...