Aberrant MCM10 SUMOylation induces genomic instability mediated by a genetic variant associated with survival of esophageal squamous cell carcinoma

• Published in: Clinical and translational medicine Vol. 11; no. 6; pp. e485 - n/a
• Main Authors: Tian, Jianbo, Lu, Zequn, Niu, Siyuan, Zhang, Shanshan, Ying, Pingting, Wang, Lu, Zhang, Ming, Cai, Yimin, Dong, Tianyi, Zhu, Ying, Zhong, Rong, Wang, Zhihua, Chang, Jiang, Miao, Xiaoping
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.06.2021; John Wiley and Sons Inc; Wiley
• Subjects: Animals; Apoptosis; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cancer therapies; Cell division; Cell Proliferation; Clinical medicine; CRISPR; Disease Progression; ESCC; Esophageal cancer; Esophageal Neoplasms - drug therapy; Esophageal Neoplasms - genetics; Esophageal Neoplasms - mortality; Esophageal Neoplasms - pathology; Esophageal Squamous Cell Carcinoma - drug therapy; Esophageal Squamous Cell Carcinoma - genetics; Esophageal Squamous Cell Carcinoma - mortality; Esophageal Squamous Cell Carcinoma - pathology; Ewings sarcoma; Female; Gene expression; Gene Expression Regulation, Neoplastic; Genomes; Genomic Instability; Humans; Licenses; MCM10; Medical prognosis; Metastasis; Mice; Mice, Inbred BALB C; Mice, Nude; Minichromosome Maintenance Proteins - chemistry; Minichromosome Maintenance Proteins - genetics; Minichromosome Maintenance Proteins - metabolism; Mutation; Plasmids; Prognosis; Proteins; Signal transduction; Squamous cell carcinoma; SUMOylation; survival; Survival analysis; Survival Rate; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; United States > US; China; MCM10; SUMOylation; genomic instability; ESCC; survival

Background Esophageal squamous cell carcinoma (ESCC) is one of the common gastrointestinal malignancy with an inferior prognosis outcome. DNA replication licensing aberration induced by dysregulation of minichromosome maintenance proteins (MCMs) causes genomic instability and cancer metastasis. SUMO...