Intravenous Lipid Infusion Induces Endoplasmic Reticulum Stress in Endothelial Cells and Blood Mononuclear Cells of Healthy Adults

• Published in: Journal of the American Heart Association Vol. 5; no. 1
• Main Authors: Tampakakis, Emmanouil, Tabit, Corey E., Holbrook, Monika, Linder, Erika A., Berk, Brittany D., Frame, Alissa A., Bretón‐Romero, Rosa, Fetterman, Jessica L., Gokce, Noyan, Vita, Joseph A., Hamburg, Naomi M.
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.01.2016; Wiley
• Subjects: Activating Transcription Factor 6 - genetics; Activating Transcription Factor 6 - metabolism; Adult; Anticoagulants - administration & dosage; Biomarkers - metabolism; Emulsions - administration & dosage; endoplasmic reticulum stress; Endoplasmic Reticulum Stress - drug effects; Endoribonucleases - metabolism; Endothelial Cells - drug effects; Endothelial Cells - metabolism; endothelium; Female; free fatty acids; Gene Expression Regulation; Healthy Volunteers; Heparin - administration & dosage; Humans; Hyperemia - physiopathology; Infusions, Intravenous; Leg - blood supply; leukocyte; Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - metabolism; Male; Microcirculation - drug effects; Original Research; Phospholipids - administration & dosage; Phospholipids - blood; Phosphorylation; Protein Phosphatase 1 - genetics; Protein Phosphatase 1 - metabolism; Protein Serine-Threonine Kinases - metabolism; Soybean Oil - administration & dosage; Soybean Oil - blood; Time Factors; Transcription Factor CHOP - genetics; Transcription Factor CHOP - metabolism; X-Box Binding Protein 1 - genetics; X-Box Binding Protein 1 - metabolism; Young Adult; endothelium; free fatty acids; endoplasmic reticulum stress; leukocyte

Background Endoplasmic reticulum (ER) stress and the subsequent unfolded protein response may initially be protective, but when prolonged, have been implicated in atherogenesis in diabetic conditions. Triglycerides and free fatty acids (FFAs) are elevated in patients with diabetes and may contribute...