Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment

• Published in: Endocrine reviews Vol. 37; no. 5; pp. 521 - 547
• Main Authors: Tebben, Peter J, Singh, Ravinder J, Kumar, Rajiv
• Format: Journal Article
• Language: English
• Published: United States Endocrine Society 01.10.2016; Oxford University Press; Copyright by The Endocrine Society
• Subjects: Animals; Calcium - blood; Humans; Hypercalcemia - diagnosis; Hypercalcemia - etiology; Hypercalcemia - therapy; Hypercalciuria - etiology; Mutation - physiology; Nephrocalcinosis - etiology; Nephrolithiasis - etiology; Reviews; Vitamin D - adverse effects; Vitamin D3 24-Hydroxylase - genetics

Hypercalcemia occurs in up to 4% of the population in association with malignancy, primary hyperparathyroidism, ingestion of excessive calcium and/or vitamin D, ectopic production of 1,25-dihydroxyvitamin D [1,25(OH)2D], and impaired degradation of 1,25(OH)2D. The ingestion of excessive amounts of v...