Bacillus subtilis ilvB operon: an intersection of global regulons

• Published in: Molecular microbiology Vol. 56; no. 6; pp. 1549 - 1559
• Main Authors: Shivers, Robert P., Sonenshein, Abraham L.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.06.2005; Blackwell Science; Blackwell Publishing Ltd
• Subjects: Amino acids; Bacillus subtilis - genetics; Bacillus subtilis - metabolism; Bacteria; Bacterial proteins; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Base Sequence; Biological and medical sciences; Biosynthesis; Chemical synthesis; DNA Footprinting; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation, Bacterial; Isoleucine - metabolism; Microbiology; Molecular Sequence Data; Operon; Promoter Regions, Genetic; Regulon - genetics; Regulon - physiology; Repressor Proteins - genetics; Repressor Proteins - metabolism; Transcription, Genetic; Valine - metabolism; Bacteria; Bacillales; Microbiology; Bacillaceae; Bacillus subtilis; Operon

Summary The genes of the major Bacillus subtilis operon (ilvB) for biosynthesis of branched‐chain amino acids are subject to multiple mechanisms of regulation. The global regulatory proteins CodY and TnrA bind upstream of the transcription start site and are likely to control transcription initiatio...