Bacillus subtilis ilvB operon: an intersection of global regulons
Summary The genes of the major Bacillus subtilis operon (ilvB) for biosynthesis of branched‐chain amino acids are subject to multiple mechanisms of regulation. The global regulatory proteins CodY and TnrA bind upstream of the transcription start site and are likely to control transcription initiatio...
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| Published in | Molecular microbiology Vol. 56; no. 6; pp. 1549 - 1559 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Science Ltd
01.06.2005
Blackwell Science Blackwell Publishing Ltd |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0950-382X 1365-2958 |
| DOI | 10.1111/j.1365-2958.2005.04634.x |
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| Abstract | Summary
The genes of the major Bacillus subtilis operon (ilvB) for biosynthesis of branched‐chain amino acids are subject to multiple mechanisms of regulation. The global regulatory proteins CodY and TnrA bind upstream of the transcription start site and are likely to control transcription initiation, leucine‐specific tRNA regulates transcriptional elongation, and unknown factors differentially cleave the full‐length mRNA. Another global regulator, CcpA, known to be required for ilvB transcription, was shown here to act directly at the ilvB promoter by a novel mechanism. Although CcpA was able to bind to the ilvB promoter region, it stimulated transcription significantly only when CodY was present, suggesting that CcpA acts primarily by interfering with repression by CodY. Additionally, CcpA was shown to control indirectly the expression of other CodY‐regulated target genes, apparently by altering the intracellular level of branched‐chain amino acids. |
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| AbstractList | The genes of the major Bacillus subtilis operon (ilvB) for biosynthesis of branched-chain amino acids are subject to multiple mechanisms of regulation. The global regulatory proteins CodY and TnrA bind upstream of the transcription start site and are likely to control transcription initiation, leucine-specific tRNA regulates transcriptional elongation, and unknown factors differentially cleave the full-length mRNA. Another global regulator, CcpA, known to be required for ilvB transcription, was shown here to act directly at the ilvB promoter by a novel mechanism. Although CcpA was able to bind to the ilvB promoter region, it stimulated transcription significantly only when CodY was present, suggesting that CcpA acts primarily by interfering with repression by CodY. Additionally, CcpA was shown to control indirectly the expression of other CodY-regulated target genes, apparently by altering the intracellular level of branched-chain amino acids. [PUBLICATION ABSTRACT] Summary The genes of the major Bacillus subtilis operon (ilvB) for biosynthesis of branched‐chain amino acids are subject to multiple mechanisms of regulation. The global regulatory proteins CodY and TnrA bind upstream of the transcription start site and are likely to control transcription initiation, leucine‐specific tRNA regulates transcriptional elongation, and unknown factors differentially cleave the full‐length mRNA. Another global regulator, CcpA, known to be required for ilvB transcription, was shown here to act directly at the ilvB promoter by a novel mechanism. Although CcpA was able to bind to the ilvB promoter region, it stimulated transcription significantly only when CodY was present, suggesting that CcpA acts primarily by interfering with repression by CodY. Additionally, CcpA was shown to control indirectly the expression of other CodY‐regulated target genes, apparently by altering the intracellular level of branched‐chain amino acids. The genes of the major Bacillus subtilis operon (ilvB) for biosynthesis of branched-chain amino acids are subject to multiple mechanisms of regulation. The global regulatory proteins CodY and TnrA bind upstream of the transcription start site and are likely to control transcription initiation, leucine-specific tRNA regulates transcriptional elongation, and unknown factors differentially cleave the full-length mRNA. Another global regulator, CcpA, known to be required for ilvB transcription, was shown here to act directly at the ilvB promoter by a novel mechanism. Although CcpA was able to bind to the ilvB promoter region, it stimulated transcription significantly only when CodY was present, suggesting that CcpA acts primarily by interfering with repression by CodY. Additionally, CcpA was shown to control indirectly the expression of other CodY-regulated target genes, apparently by altering the intracellular level of branched-chain amino acids. The genes of the major Bacillus subtilis operon (ilvB) for biosynthesis of branched-chain amino acids are subject to multiple mechanisms of regulation. The global regulatory proteins CodY and TnrA bind upstream of the transcription start site and are likely to control transcription initiation, leucine-specific tRNA regulates transcriptional elongation, and unknown factors differentially cleave the full-length mRNA. Another global regulator, CcpA, known to be required for ilvB transcription, was shown here to act directly at the ilvB promoter by a novel mechanism. Although CcpA was able to bind to the ilvB promoter region, it stimulated transcription significantly only when CodY was present, suggesting that CcpA acts primarily by interfering with repression by CodY. Additionally, CcpA was shown to control indirectly the expression of other CodY-regulated target genes, apparently by altering the intracellular level of branched-chain amino acids.The genes of the major Bacillus subtilis operon (ilvB) for biosynthesis of branched-chain amino acids are subject to multiple mechanisms of regulation. The global regulatory proteins CodY and TnrA bind upstream of the transcription start site and are likely to control transcription initiation, leucine-specific tRNA regulates transcriptional elongation, and unknown factors differentially cleave the full-length mRNA. Another global regulator, CcpA, known to be required for ilvB transcription, was shown here to act directly at the ilvB promoter by a novel mechanism. Although CcpA was able to bind to the ilvB promoter region, it stimulated transcription significantly only when CodY was present, suggesting that CcpA acts primarily by interfering with repression by CodY. Additionally, CcpA was shown to control indirectly the expression of other CodY-regulated target genes, apparently by altering the intracellular level of branched-chain amino acids. The genes of the major Bacillus subtilis operon ( ilvB ) for biosynthesis of branched‐chain amino acids are subject to multiple mechanisms of regulation. The global regulatory proteins CodY and TnrA bind upstream of the transcription start site and are likely to control transcription initiation, leucine‐specific tRNA regulates transcriptional elongation, and unknown factors differentially cleave the full‐length mRNA. Another global regulator, CcpA, known to be required for ilvB transcription, was shown here to act directly at the ilvB promoter by a novel mechanism. Although CcpA was able to bind to the ilvB promoter region, it stimulated transcription significantly only when CodY was present, suggesting that CcpA acts primarily by interfering with repression by CodY. Additionally, CcpA was shown to control indirectly the expression of other CodY‐regulated target genes, apparently by altering the intracellular level of branched‐chain amino acids. |
| Author | Sonenshein, Abraham L. Shivers, Robert P. |
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The genes of the major Bacillus subtilis operon (ilvB) for biosynthesis of branched‐chain amino acids are subject to multiple mechanisms of regulation.... The genes of the major Bacillus subtilis operon ( ilvB ) for biosynthesis of branched‐chain amino acids are subject to multiple mechanisms of regulation. The... The genes of the major Bacillus subtilis operon (ilvB) for biosynthesis of branched-chain amino acids are subject to multiple mechanisms of regulation. The... |
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| SubjectTerms | Amino acids Bacillus subtilis - genetics Bacillus subtilis - metabolism Bacteria Bacterial proteins Bacterial Proteins - genetics Bacterial Proteins - metabolism Base Sequence Biological and medical sciences Biosynthesis Chemical synthesis DNA Footprinting DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial Isoleucine - metabolism Microbiology Molecular Sequence Data Operon Promoter Regions, Genetic Regulon - genetics Regulon - physiology Repressor Proteins - genetics Repressor Proteins - metabolism Transcription, Genetic Valine - metabolism |
| Title | Bacillus subtilis ilvB operon: an intersection of global regulons |
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