Effect of a Novel Ascorbic Derivative, Disodium Isostearyl 2-O-L-Ascorbyl Phosphate on Human Dermal Fibroblasts: Increased Collagen Synthesis and Inhibition of MMP-1

• Published in: Biological & Pharmaceutical Bulletin Vol. 31; no. 4; pp. 563 - 568
• Main Authors: Shibayama, Hiroharu, Hisama, Masayoshi, Matsuda, Sanae, Ohtsuki, Mamitaro, Iwaki, Masahiro
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.04.2008; Pharmaceutical Society of Japan
• Subjects: amphiphilic vitamin C derivative; Ascorbic Acid - analogs & derivatives; Ascorbic Acid - metabolism; Ascorbic Acid - pharmacology; Cell Proliferation - drug effects; Cells, Cultured; Chromatography, High Pressure Liquid; Collagen - antagonists & inhibitors; Collagen - biosynthesis; collagen synthesis; disodium isostearyl 2-O-L-ascorbyl phosphate; Extracellular Matrix - metabolism; Fibroblasts - drug effects; Fibroblasts - metabolism; human skin fibroblast; Humans; Magnetic Resonance Spectroscopy; Matrix Metalloproteinase Inhibitors; Skin - cytology; Skin - drug effects; Skin - metabolism; VCP-IS-2Na

The effects of a novel amphiphilic vitamin C derivative, disodium isostearyl 2-O-L-ascorbyl phosphate (disodium 2-(1,3,3-trimethyl-n-butyl)-5,7,7-trimethyl-n-octyl-L-ascorbyl phosphate, VCP-IS-2Na), possessing a C18 alkyl chain attached to a stable sodium L-ascorbic acid 2-phosphate (VCP-Na), on the...