Aortic Valve Stenosis Alters Expression of Regional Aortic Wall Shear Stress: New Insights From a 4‐Dimensional Flow Magnetic Resonance Imaging Study of 571 Subjects

• Published in: Journal of the American Heart Association Vol. 6; no. 9
• Main Authors: Ooij, Pim, Markl, Michael, Collins, Jeremy D., Carr, James C., Rigsby, Cynthia, Bonow, Robert O., Malaisrie, S. Chris, McCarthy, Patrick M., Fedak, Paul W.M., Barker, Alex J.
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.09.2017; Wiley
• Subjects: Adult; Aged; Aorta, Thoracic - diagnostic imaging; Aorta, Thoracic - physiopathology; Aortic Aneurysm, Thoracic - diagnostic imaging; Aortic Aneurysm, Thoracic - etiology; Aortic Aneurysm, Thoracic - physiopathology; aortic disease; aortic valve; Aortic Valve - abnormalities; Aortic Valve - diagnostic imaging; Aortic Valve - physiopathology; aortic valve stenosis; Aortic Valve Stenosis - diagnostic imaging; Aortic Valve Stenosis - etiology; Aortic Valve Stenosis - physiopathology; bicuspid aortic valve; Bicuspid Aortic Valve Disease; Blood Flow Velocity; Cross-Sectional Studies; Databases, Factual; Female; Heart Valve Diseases - complications; Heart Valve Diseases - diagnostic imaging; Heart Valve Diseases - physiopathology; Hemodynamics; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Original Research; Phenotype; Predictive Value of Tests; Regional Blood Flow; Retrospective Studies; Severity of Illness Index; Stress, Mechanical; aortic valve stenosis; aortic valve; magnetic resonance imaging; bicuspid aortic valve; aortic disease

Background Wall shear stress (WSS) is a stimulus for vessel wall remodeling. Differences in ascending aorta (AAo) hemodynamics have been reported between bicuspid aortic valve (BAV) and tricuspid aortic valve patients with aortic dilatation, but the confounding impact of aortic valve stenosis (AS) i...