Organoiridium Photosensitizers Induce Specific Oxidative Attack on Proteins within Cancer Cells

• Published in: Angewandte Chemie International Edition Vol. 56; no. 47; pp. 14898 - 14902
• Main Authors: Zhang, Pingyu, Chiu, Cookson K. C., Huang, Huaiyi, Lam, Yuko P. Y., Habtemariam, Abraha, Malcomson, Thomas, Paterson, Martin J., Clarkson, Guy J., O'Connor, Peter B., Chao, Hui, Sadler, Peter J.
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 20.11.2017; John Wiley and Sons Inc
• Edition: International ed. in English
• Subjects: A549 Cells; Absorption cross sections; Aldehyde reductase; bioinorganic; Cancer; cells; Chelating Agents - chemistry; Chelation; Communication; Communications; Crystallography; Crystallography, X-Ray; Cytotoxicity; Density Functional Theory; Glycolysis; Heat shock proteins; Histidine; Histidine - chemistry; Humans; Iridium; Iridium - chemistry; Iridium compounds; Irradiation; Ligands; Luminescence; Multicellular tumor spheroids; Neoplasm Proteins - chemistry; Neoplasm Proteins - metabolism; Organometallic Compounds - chemistry; Organometallic Compounds - pharmacology; Oxidation-Reduction; Oxidative stress; Oxidative Stress - drug effects; Phosphorescence; Photoactivation; Photochemical Processes; Photon absorption; photosensitizers; Photosensitizing Agents - pharmacology; Quinolines - chemistry; Spheroids; Spheroids, Cellular - drug effects; X-ray crystallography; bioinorganic; iridium; cancer; cells; photosensitizers

Strongly luminescent iridium(III) complexes, [Ir(C,N)2(S,S)]+ (1) and [Ir(C,N)2(O,O)] (2), containing C,N (phenylquinoline), O,O (diketonate), or S,S (dithione) chelating ligands, have been characterized by X‐ray crystallography and DFT calculations. Their long phosphorescence lifetimes in living ca...