Association of serum surfactant protein D and SFTPD gene variants with asthma in Danish children, adolescents, and young adults

• Published in: Immunity, Inflammation and Disease Vol. 10; no. 2; pp. 189 - 200
• Main Authors: Hoffmann‐Petersen, Benjamin, Suffolk, Raymond, Petersen, Jens J. H., Petersen, Thomas H., Brasch‐Andersen, Charlotte, Høst, Arne, Halken, Susanne, Sorensen, Grith L., Agertoft, Lone
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.02.2022; John Wiley and Sons Inc; Wiley
• Subjects: Adolescent; Adult; Allergens; Allergies; Asthma; Asthma - genetics; biomarker; Child; Classification; Confidence intervals; Data collection; Denmark - epidemiology; Genotype; Humans; Lung; Normal distribution; Original; Pediatrics; Proteins; Pulmonary Surfactant-Associated Protein D - blood; Pulmonary Surfactant-Associated Protein D - genetics; Quality of life; Questionnaires; Regression analysis; Spirometry; Statistical analysis; surfactant protein D; Surfactants; Teenagers; Values; Young Adult; Young adults; Denmark; adolescent; asthma; biomarker; surfactant protein D; child

Background Surfactant Protein D (SP‐D) is a pattern recognition molecule belonging to the family of collectins expressed in multiple human organ systems, including the lungs. Previous studies have shown that SP‐D levels in bronchoalveolar lavage samples decrease and serum levels increase in patients...