Synthetic retinoid-mediated preconditioning of cancer-associated fibroblasts and macrophages improves cancer response to immune checkpoint blockade

• Published in: British Journal of Cancer Vol. 131; no. 2; pp. 372 - 386
• Main Authors: Owaki, Takayuki, Iida, Tadashi, Miyai, Yuki, Kato, Katsuhiro, Hase, Tetsunari, Ishii, Makoto, Ando, Ryota, Hinohara, Kunihiko, Akashi, Tomohiro, Mizutani, Yasuyuki, Ishikawa, Takuya, Mii, Shinji, Shiraki, Yukihiro, Esaki, Nobutoshi, Yamamoto, Masami, Tsukamoto, Tetsuya, Nomura, Sachiyo, Murakami, Takashi, Takahashi, Masahide, Yuguchi, Yuri, Maeda, Motohiro, Sano, Tomoyasu, Sassa, Naoto, Matsukawa, Yoshihisa, Kawashima, Hiroki, Akamatsu, Shusuke, Enomoto, Atsushi
• Format: Journal Article
• Language: English
• Published: London Springer Science and Business Media LLC 22.07.2024; Nature Publishing Group UK; Nature Publishing Group
• Subjects: 631/67/327; 692/308/575; Animal models; Animals; Benzoates; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer Research; Cancer-Associated Fibroblasts - drug effects; Cancer-Associated Fibroblasts - metabolism; Carcinoma, Renal Cell - drug therapy; Carcinoma, Renal Cell - immunology; Carcinoma, Renal Cell - pathology; Cell Line, Tumor; Clear cell-type renal cell carcinoma; Drug delivery; Drug Resistance; Epidemiology; Female; Fibroblasts; Humans; Immune checkpoint inhibitors; Immune Checkpoint Inhibitors - pharmacology; Immune Checkpoint Inhibitors - therapeutic use; Infiltration; Kidney cancer; Kidney Neoplasms - drug therapy; Kidney Neoplasms - immunology; Kidney Neoplasms - pathology; Macrophages; Macrophages - drug effects; Macrophages - immunology; Macrophages - metabolism; Metastases; Mice; Microenvironments; Molecular Medicine; Oncology; Phenotypes; Retinoids - pharmacology; Retinoids - therapeutic use; Tetrahydronaphthalenes - pharmacology; Tumor Microenvironment - drug effects; Tumor Microenvironment - immunology; Tumor-Associated Macrophages - drug effects; Tumor-Associated Macrophages - immunology; Tumor-Associated Macrophages - metabolism; Tumors; Urological cancer; Urothelial carcinoma

Background The proliferation of cancer-associated fibroblasts (CAFs) hampers drug delivery and anti-tumor immunity, inducing tumor resistance to immune checkpoint blockade (ICB) therapy. However, it has remained a challenge to develop therapeutics that specifically target or modulate CAFs. Methods W...