Synthetic retinoid-mediated preconditioning of cancer-associated fibroblasts and macrophages improves cancer response to immune checkpoint blockade - Owaki, Takayuki; Iida, Tadashi; Miyai, Yuki; Kato, Katsuhiro; Hase, Tetsunari; Ishii, Makoto; Ando, Ryota; Hinohara, Kunihiko; Akashi, Tomohiro; Mizutani, Yasuyuki; Ishikawa, Takuya; Mii, Shinji; et al. (British Journal of Cancer, 2024)
Keywords: 631/67/327; 692/308/575; Animal models; Animals; Benzoates; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer Research; Cancer-Associated Fibroblasts - drug effects; Cancer-Associated Fibroblasts - metabolism; Carcinoma, Renal Cell - drug therapy; Carcinoma, Renal Cell - immunology; Carcinoma, Renal Cell - pathology; Cell Line, Tumor; Clear cell-type renal cell carcinoma; Drug delivery; Drug Resistance; Epidemiology; Female; Fibroblasts; Humans; Immune checkpoint inhibitors; Immune Checkpoint Inhibitors - pharmacology; Immune Checkpoint Inhibitors - therapeutic use; Infiltration; Kidney cancer; Kidney Neoplasms - drug therapy; Kidney Neoplasms - immunology; Kidney Neoplasms - pathology; Macrophages; Macrophages - drug effects; Macrophages - immunology; Macrophages - metabolism; Metastases; Mice; Microenvironments; Molecular Medicine; Oncology; Phenotypes; Retinoids - pharmacology; Retinoids - therapeutic use; Tetrahydronaphthalenes - pharmacology; Tumor Microenvironment - drug effects; Tumor Microenvironment - immunology; Tumor-Associated Macrophages - drug effects; Tumor-Associated Macrophages - immunology; Tumor-Associated Macrophages - metabolism; Tumors; Urological cancer; Urothelial carcinoma