Renal Fibrosis: SIRT1 Still of Value

• Published in: Biomedicines Vol. 12; no. 9; p. 1942
• Main Authors: Wu, Huailiang, Qiu, Zhen, Wang, Liyan, Li, Wei
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.09.2024; MDPI
• Subjects: Adenosine; Aging; Amino acids; Apoptosis; Autophagy; Cell cycle; Development and progression; DNA methylation; End-stage renal disease; Energy; Extracellular matrix; Fatty acids; Fibroblasts; Fibrosis; Health aspects; Histones; Homeostasis; Inflammation; Kidney diseases; Lipid metabolism; Metabolism; Metabolites; NAD; Oxidation; Oxidative metabolism; Oxidative stress; Physiological aspects; Physiology; Proteins; Public health; renal fibrosis; Review; Ribosomal DNA; SIRT1; SIRT1 protein; Stem cells; Therapeutic targets; Transcription factors; Trimetazidine; China; aging; renal fibrosis; SIRT1; oxidative stress; lipid metabolism

Chronic kidney disease (CKD) is a major global health concern. Renal fibrosis, a prevalent outcome regardless of the initial cause, ultimately leads to end-stage renal disease. Glomerulosclerosis and renal interstitial fibrosis are the primary pathological features. Preventing and slowing renal fibr...