Singlet Oxygen Induced Products of Linoleates, 10- and 12-(Z,E)-Hydroxyoctadecadienoic Acids (HODE), Can Be Potential Biomarkers for Early Detection of Type 2 Diabetes

• Published in: PloS one Vol. 8; no. 5; p. e63542
• Main Authors: Umeno, Aya, Shichiri, Mototada, Ishida, Noriko, Hashimoto, Yoshiko, Abe, Kaori, Kataoka, Masatoshi, Yoshino, Kohzoh, Hagihara, Yoshihisa, Aki, Nanako, Funaki, Makoto, Asada, Yasuhiko, Yoshida, Yasukazu
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 15.05.2013; Public Library of Science (PLoS)
• Subjects: Acids; Adipokines - blood; Adiponectin; Adult; Bioindicators; Biology; Biomarkers; Biomarkers - blood; C-reactive protein; Chemistry; Cholesterol; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - diagnosis; Diagnostic systems; Disease; Early Diagnosis; Fasting; Fatty Acids, Unsaturated - blood; Female; Gas Chromatography-Mass Spectrometry; Gene expression; Glucose; Glucose tolerance; Glucose Tolerance Test; Hemoglobin; Hospitals; Humans; In vivo methods and tests; Insulin; Insulin resistance; Insulin secretion; Interleukin 6; Laboratory testing; Leptin; Linoleic acid; Linoleic Acids - blood; Lipid peroxidation; Lipids; Male; Medical research; Medicine; Metabolism; Metabolites; Middle Aged; Oxidants; Oxidation; Oxidative Stress; Oxidizing agents; Oxygen; Peroxidation; Phosphine; Potassium; Potassium hydroxide; Potassium hydroxides; Rodents; Science; Singlet oxygen; Singlet Oxygen - metabolism; Studies; Tumor necrosis factor-α

Current diagnostic tests such as glycemic indicators have limitations for early detection of impaired glucose tolerance (IGT), which leads to diabetes. Oxidative stress induced by various oxidants in a random and destructive manner is considered to play an important role in the pathophysiology of a...