Evaluation of efficacy, biodistribution and safety of antibiotic-free plasmid encoding somatostatin genes delivered by attenuated Salmonella enterica serovar Choleraesuis - Liang, Aixin; Riaz, Hasan; Dong, Fangxiao; Luo, Xuan; Yu, Xue; Han, Yanguo; Chong, Zhenlu; Han, Li; Guo, Aizhen; Yang, Liguo (Vaccine, 2014)
Keywords: Administration, Oral; Allergy and Immunology; Animals; antibiotic resistance; antibodies; Applied microbiology; Aspartate-Semialdehyde Dehydrogenase - genetics; bacteria; Bacteriology; Biological and medical sciences; brain; DNA vaccine; domestic animals; Female; Fundamental and applied biological sciences. Psychology; genes; Genes, Reporter; Immunity, Humoral; immunoglobulin A; immunoglobulin G; Immunoglobulin G - blood; Mice; Mice, Inbred BALB C; Microbiology; Miscellaneous; mutants; plasmids; Plasmids - genetics; Plasmids - immunology; Plasmids - pharmacokinetics; recombinant vaccines; risk; Safety; Salmonella; Salmonella choleraesuis Choleraesuis; Salmonella enterica; Salmonella enterica - genetics; Salmonella enterica - immunology; Somatostatin; Somatostatin - genetics; Somatostatin - immunology; Tissue Distribution; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, DNA - genetics; Vaccines, DNA - immunology; DNA vaccine; Salmonella; Mice; Somatostatin; Safety; Peptide hormone; Rodentia; Genetic vaccine; Neuropeptide; Plasmid; Vertebrata; Antibiotic; Mammalia; Gene; Mouse; Efficiency; Salmonella choleraesuis; Bacteria; Enterobacteriaceae