Global epigenetic profiling identifies methylation subgroups associated with recurrence-free survival in meningioma

• Published in: Acta neuropathologica Vol. 133; no. 3; pp. 431 - 444
• Main Authors: Olar, Adriana, Wani, Khalida M., Wilson, Charmaine D., Zadeh, Gelareh, DeMonte, Franco, Jones, David T. W., Pfister, Stefan M., Sulman, Erik P., Aldape, Kenneth D.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2017; Springer; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Brain research; Cancer; Disease-Free Survival; DNA Copy Number Variations - genetics; DNA methylation; DNA Methylation - physiology; Epigenetic inheritance; Epigenetics; Epigenomics - methods; Female; Follow-Up Studies; Humans; Ki-67 Antigen - metabolism; Male; Medical prognosis; Medical research; Medicine; Medicine & Public Health; Meningeal Neoplasms - mortality; Meningioma; Meningioma - mortality; Methylation; Middle Aged; Morphology; Neoplasm Recurrence, Local - mortality; Neurosciences; Neurosurgery; Oncology; Original Paper; Pathology; Pediatrics; Radiation therapy; Statistics, Nonparametric; Tumors; Young Adult; Canada; United States > US; Germany; Epigenetics; DNA methylation; Recurrence risk; Copy number aberrations; Molecular subgroups; Meningioma

Meningioma is the most common primary brain tumor and carries a substantial risk of local recurrence. Methylation profiles of meningioma and their clinical implications are not well understood. We hypothesized that aggressive meningiomas have unique DNA methylation patterns that could be used to bet...