Derivation of Embryonic Stem-Cell Lines from Human Blastocysts

This report, first published online on March 3, 2004, discusses the procedures used to develop 17 lines of human embryonic stem cells from the inner cell masses of blastocysts. These cell lines are available to researchers under a Material Transfer Agreement; according to current regulations, the ce...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 350; no. 13; pp. 1353 - 1356
Main Authors Cowan, Chad A, Klimanskaya, Irina, McMahon, Jill, McMahon, Andrew P, Atienza, Jocelyn, Witmyer, Jeannine, Zucker, Jacob P, Wang, Shunping, Morton, Cynthia C, Powers, Doug, Melton, Douglas A
Format Journal Article
LanguageEnglish
Published Boston, MA Massachusetts Medical Society 25.03.2004
Subjects
Biological and medical sciences
Blastocyst - cytology
Cell Line
Cell Lineage
Embryo, Mammalian - cytology
Embryos
General aspects
Humans
Medical research
Medical sciences
Proteins
Stem Cells
Human
Medicine
Cell line
Embryonic cell
Stem cell
Blastocyst
Established cell line
Hematopoietic cell
Genetics and Reproduction
Biomedical and Behavioral Research
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Summary:This report, first published online on March 3, 2004, discusses the procedures used to develop 17 lines of human embryonic stem cells from the inner cell masses of blastocysts. These cell lines are available to researchers under a Material Transfer Agreement; according to current regulations, the cells cannot be used for research supported by federal funds. These cells are expected to facilitate research on a variety of serious chronic diseases. The 17 new cell lines described here are being made available to researchers. Embryonic stem cells have the unique ability to form all adult cell types. Harnessing this potential may provide a source of cells to replace those that are lost or impaired as a result of disease. Moreover, the derivation of human embryonic stem cells opens a unique window into the study of early human development. At present, approximately 15 human embryonic stem-cell lines are publicly available, and they vary considerably in their usefulness for research and the extent of their characterization (see http://stemcells.nih.gov/registry/index.asp). To promote further research with human embryonic stem cells, we sought to derive and characterize more fully cell . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMsr040330