Association Between Composition of the Human Gastrointestinal Microbiome and Development of Fatty Liver With Choline Deficiency

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 140; no. 3; pp. 976 - 986
• Main Authors: Spencer, Melanie D., Hamp, Timothy J., Reid, Robert W., Fischer, Leslie M., Zeisel, Steven H., Fodor, Anthony A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2011
• Subjects: Adult; Bacteria; Choline Deficiency - complications; Choline Deficiency - genetics; Choline Deficiency - microbiology; Choline Metabolism; Cluster Analysis; Fatty Liver - diagnosis; Fatty Liver - etiology; Fatty Liver - microbiology; Feces - microbiology; Female; Gastroenterology and Hepatology; Gastrointestinal Tract - microbiology; Genetic Predisposition to Disease; Hepatic Steatosis; Humans; Magnetic Resonance Imaging; Metagenome; Non-alcoholic Fatty Liver Disease; North Carolina; Phosphatidylcholine; Phosphatidylethanolamine N-Methyltransferase - genetics; Polymorphism, Single Nucleotide; Principal Component Analysis; Promoter Regions, Genetic; Ribotyping; Risk Assessment; Risk Factors; Time Factors; North Carolina; OTU; SNP; Hepatic Steatosis; MRI; LF/SF; Phosphatidylcholine; Bacteria; ARISA; Choline Metabolism; PCR; PCA; RDP; magnetic resonance imaging; single nucleotide polymorphism; operational taxonomic unit; principal components analysis; liver fat to spleen fat ratio; Ribosomal Database Project; automated ribosomal intergenic sequence analysis; polymerase chain reaction

Nonalcoholic fatty liver disease affects up to 30% of the US population, but the mechanisms underlying this condition are incompletely understood. We investigated how diet standardization and choline deficiency influence the composition of the microbial community in the human gastrointestinal tract...